IRS2


Summary: This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
insulin receptor substrate 2MIM:600797Ensembl:ENSG00000185950HGNC:HGNC:6126PA37513q34

GO terms in IRS2


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIEAGO:0032991protein-containing complex
BPTASGO:0000165MAPK cascade
BPIEAGO:0002053positive regulation of mesenchymal cell proliferation
BPISSGO:0002903negative regulation of B cell apoptotic process
BPTASGO:0006006glucose metabolic process
BPTASGO:0007165signal transduction
BPTASGO:0007411axon guidance
BPIEAGO:0007420brain development
BPIEAGO:0008283cell proliferation
BPNASGO:0008284positive regulation of cell proliferation
BPIBAGO:0008286insulin receptor signaling pathway
BPISSGO:0008286insulin receptor signaling pathway
BPISSGO:0009749response to glucose
BPIMPGO:0010748negative regulation of plasma membrane long-chain fatty acid transport
BPIMPGO:0010907positive regulation of glucose metabolic process
BPIBAGO:0019216regulation of lipid metabolic process
BPTASGO:0019216regulation of lipid metabolic process
BPIEAGO:0030335positive regulation of cell migration
BPIEAGO:0030879mammary gland development
BPISSGO:0030890positive regulation of B cell proliferation
BPIMPGO:0032000positive regulation of fatty acid beta-oxidation
BPISSGO:0032024positive regulation of insulin secretion
BPIMPGO:0032869cellular response to insulin stimulus
BPISSGO:0033673negative regulation of kinase activity
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPTASGO:0038111interleukin-7-mediated signaling pathway
BPIMPGO:0045725positive regulation of glycogen biosynthetic process
BPNASGO:0045725positive regulation of glycogen biosynthetic process
BPIMPGO:0046326positive regulation of glucose import
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPTASGO:0048015phosphatidylinositol-mediated signaling
BPTASGO:0051897positive regulation of protein kinase B signaling
BPTASGO:0055088lipid homeostasis
BPIEAGO:0071333cellular response to glucose stimulus
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIBAGO:0005158insulin receptor binding
MFIPIGO:0005515protein binding
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFIEAGO:0019901protein kinase binding
MFIEAGO:0019903protein phosphatase binding
MFIEAGO:0019904protein domain specific binding
MFIBAGO:0043548phosphatidylinositol 3-kinase binding
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
MFIEAGO:007188914-3-3 protein binding

Gene expression in normal tissue: IRS2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in IRS2


DatabasePathway IDPathway Des.
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-112412SOS-mediated signalling
reactomeR-HSA-112412SOS-mediated signalling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-198203PI3K/AKT activation
reactomeR-HSA-198203PI3K/AKT activation
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-2586552Signaling by Leptin
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74713IRS activation
reactomeR-HSA-74749Signal attenuation
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-8853659RET signaling
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-982772Growth hormone receptor signaling
pidepopathwayEPO signaling pathway
pidigf1_pathwayIGF1 pathway
pidil2_1pathwayIL2-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidret_pathwaySignaling events regulated by Ret tyrosine kinase
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04140Autophagy - animal - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
kegghsa04211Longevity regulating pathway - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04910Insulin signaling pathway - Homo sapiens (human)
kegghsa04920Adipocytokine signaling pathway - Homo sapiens (human)
kegghsa04923Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegghsa04930Type II diabetes mellitus - Homo sapiens (human)
kegghsa04931Insulin resistance - Homo sapiens (human)
kegghsa04932Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
pharmgkbPA153627758Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
netpathPathway_Alpha6Beta4IntegrinAlpha6Beta4Integrin
netpathPathway_BDNFBDNF
netpathPathway_EGFR1EGFR1
netpathPathway_IL-7IL-7
netpathPathway_IL2IL2
netpathPathway_IL4IL4
netpathPathway_LeptinLeptin
smpdbSMP00391Insulin Signalling
smpdbSMP00682Leucine Stimulation on Insulin Signaling
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP236Adipogenesis
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP244Alpha 6 Beta 4 signaling pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP2879Farnesoid X Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP3599Transcription factor regulation in adipogenesis
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP3935Leptin Insulin Overlap
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP581EPO Receptor Signaling
wikipathwaysWP585Interferon type I signaling pathways

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD414MST-3123
iGMDRD506Fedratinib6
iGMDRD780PP-301
iGMDRD152179324-69-76
iGMDRD300Tozasertib3
iGMDRD137Indisulam6
iGMDRD105Triptolide3
iGMDRD424Tamatinib3
iGMDRD481Dactolisib3
iGMDRD77Itraconazole3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IRS2

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