MAPK6
Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase 6 | MIM:602904 | Ensembl:ENSG00000069956 | HGNC:HGNC:6879 | PA30624 | 15q21.2 |
GO terms in MAPK6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0032156 | septin cytoskeleton |
| CC | IEA | GO:0032991 | protein-containing complex |
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IBA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IBA | GO:0010468 | regulation of gene expression |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0060999 | positive regulation of dendritic spine development |
| BP | IBA | GO:0071310 | cellular response to organic substance |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004707 | MAP kinase activity |
| MF | ISS | GO:0004707 | MAP kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: MAPK6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAPK6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP26 | Signal Transduction of S1P Receptor |
| wikipathways | WP3307 | MAPK6-MAPK4 signaling |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5687128 | MAPK6/MAPK4 signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD718 | Pyrvinium pamoate | 3 |
| iGMDRD398 | Sepantronium | 6 |
| iGMDRD152 | 179324-69-7 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAPK6
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.