SCD5


Summary: Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
stearoyl-CoA desaturase 5MIM:608370Ensembl:ENSG00000145284HGNC:HGNC:21088PA1349346924q21.22

Gene Categories:

DRUGGABLE GENOME

GO terms in SCD5


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006636unsaturated fatty acid biosynthetic process
BPTASGO:0046949fatty-acyl-CoA biosynthetic process
BPIEAGO:0055114oxidation-reduction process
BPIBAGO:1903966monounsaturated fatty acid biosynthetic process
CCIBAGO:0005789endoplasmic reticulum membrane
CCIDAGO:0005789endoplasmic reticulum membrane
CCTASGO:0005789endoplasmic reticulum membrane
CCIEAGO:0016021integral component of membrane
MFEXPGO:0004768stearoyl-CoA 9-desaturase activity
MFIBAGO:0004768stearoyl-CoA 9-desaturase activity
MFIDAGO:0004768stearoyl-CoA 9-desaturase activity
MFIBAGO:0005506iron ion binding
MFIDAGO:0016491oxidoreductase activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: SCD5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SCD5


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-75105Fatty acyl-CoA biosynthesis
reactomeR-HSA-8978868Fatty acid metabolism
kegghsa01040Biosynthesis of unsaturated fatty acids - Homo sapiens (human)
kegghsa03320PPAR signaling pathway - Homo sapiens (human)
kegghsa04152AMPK signaling pathway - Homo sapiens (human)
humancycPWY-5996oleate biosynthesis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD451Serdemetan3
iGMDRD74Idarubicin2
iGMDRD562Navitoclax6
iGMDRD171Pemetrexed1
iGMDRD294Batimastat3
iGMDRD187BRD98762
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD137Indisulam3
iGMDRD158NSC1415403
iGMDRD8024-methylfasudil3
iGMDRD177Teniposide1
iGMDRD154NSC237666
iGMDRD375GW-4058333
iGMDRD314Tanespimycin2
iGMDRD427ABT7376
iGMDRD512nutlin 33

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SCD5

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