TTF1


Summary: This gene encodes a transcription termination factor that is localized to the nucleolus and plays a critical role in ribosomal gene transcription. The encoded protein mediates the termination of RNA polymerase I transcription by binding to Sal box terminator elements downstream of pre-rRNA coding regions. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. This gene shares the symbol/alias 'TFF1' with another gene, NK2 homeobox 1, also known as thyroid transcription factor 1, which plays a role in the regulation of thyroid-specific gene expression. [provided by RefSeq, Apr 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
transcription termination factor 1MIM:600777Ensembl:ENSG00000125482HGNC:HGNC:12397PA370629q34.13

GO terms in TTF1


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCNASGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005730nucleolus
CCIDAGO:0005829cytosol
CCIDAGO:0005886plasma membrane
BPNASGO:0006353DNA-templated transcription, termination
BPTASGO:0006363termination of RNA polymerase I transcription
BPIEAGO:0008156negative regulation of DNA replication
BPTASGO:0044267cellular protein metabolic process

Gene expression in normal tissue: TTF1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TTF1


DatabasePathway IDPathway Des.
reactomeR-HSA-1643685Disease
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-427389ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
reactomeR-HSA-427413NoRC negatively regulates rRNA expression
reactomeR-HSA-5250913Positive epigenetic regulation of rRNA expression
reactomeR-HSA-5250941Negative epigenetic regulation of rRNA expression
reactomeR-HSA-5668914Diseases of metabolism
reactomeR-HSA-5683826Surfactant metabolism
reactomeR-HSA-5687613Diseases associated with surfactant metabolism
reactomeR-HSA-5688031Defective pro-SFTPB causes pulmonary surfactant metabolism dysfunction 1 (SMDP1) and respiratory distress syndrome (RDS)
reactomeR-HSA-73762RNA Polymerase I Transcription Initiation
reactomeR-HSA-73854RNA Polymerase I Promoter Clearance
reactomeR-HSA-73863RNA Polymerase I Transcription Termination
reactomeR-HSA-73863RNA Polymerase I Transcription Termination
reactomeR-HSA-73864RNA Polymerase I Transcription
reactomeR-HSA-73864RNA Polymerase I Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD422Regorafenib1
iGMDRD491TAE-6841
iGMDRD439KW-24491
iGMDRD622BRD-K785743271
iGMDRD379BIBR-15321
iGMDRD272GSK-3 Inhibitor IX1
iGMDRD620BRD-K413341191
iGMDRD431NU-74411
iGMDRD552AZD-17751
iGMDRD625BRD-K848074111
iGMDRD304CH 551
iGMDRD602Foretinib1
iGMDRD382CEP-7011
iGMDRD262KU-559331
iGMDRD410Ko-1431
iGMDRD387CHIR-990211
iGMDRD659Avagacestat (BMS-708163)1
iGMDRD546BMS-7548071
iGMDRD844BRD-A943779141
iGMDRD78Topotecan1
iGMDRD385CD15301
iGMDRD154NSC237661

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TTF1

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