CAMKK1


Summary: The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
calcium/calmodulin dependent protein kinase kinase 1MIM:611411Ensembl:ENSG00000004660HGNC:HGNC:1469PA2605117p13.2

GO terms in CAMKK1


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004683calmodulin-dependent protein kinase activity
MFTASGO:0004683calmodulin-dependent protein kinase activity
MFIPIGO:0005515protein binding
MFIBAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
CCIBAGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCTASGO:0005829cytosol
BPIBAGO:0035556intracellular signal transduction
BPIBAGO:0045860positive regulation of protein kinase activity

Gene expression in normal tissue: CAMKK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CAMKK1


DatabasePathway IDPathway Des.
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-442717CREB phosphorylation through the activation of CaMKK
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
biocartacacampathwayca-calmodulin-dependent protein kinase activation
biocartafmlppathwayfmlp induced chemokine gene expression in hmc-1 cells
biocartanfatpathwaynfat and hypertrophy of the heart
biocartapgc1apathwayregulation of pgc-1a
kegghsa05034Alcoholism - Homo sapiens (human)
wikipathwaysWP1403AMP-activated Protein Kinase (AMPK) Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD188Piperlongumine3
iGMDRD286Nsc 6328393
iGMDRD872BRD71373
iGMDRD60Quinoclamine3
iGMDRD271Brefeldin A1
iGMDRD137Indisulam1
iGMDRD158NSC1415402
iGMDRD221Tamoxifen3
iGMDRD77Itraconazole3
iGMDRD499PDMP3
iGMDRD394BX-7955
iGMDRD679Bistramide A2
iGMDRD280CYTOCHALASIN B3
iGMDRD883CIL55A3
iGMDRD889Compound 7d-cis3
iGMDRD546BMS-7548073
iGMDRD483SCH-5290743
iGMDRD405PIK-753

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CAMKK1

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