DAND5


Summary: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DAN domain BMP antagonist family member 5MIM:609068Ensembl:ENSG00000179284HGNC:HGNC:26780PA13487526819p13.13

Gene Categories:

DRUGGABLE GENOME

GO terms in DAND5


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0016015morphogen activity
MFISSGO:0016015morphogen activity
CCNASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
BPISSGO:0003140determination of left/right asymmetry in lateral mesoderm
BPISSGO:0003281ventricular septum development
BPISSGO:0003283atrial septum development
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0023019signal transduction involved in regulation of gene expression
BPISSGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPISSGO:0030514negative regulation of BMP signaling pathway
BPIBAGO:0035582sequestering of BMP in extracellular matrix
BPISSGO:0038101sequestering of nodal from receptor via nodal binding
BPIBAGO:0061371determination of heart left/right asymmetry
BPISSGO:0061371determination of heart left/right asymmetry
BPISSGO:1900108negative regulation of nodal signaling pathway
BPIBAGO:1900176negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Gene expression in normal tissue: DAND5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DAND5


DatabasePathway IDPathway Des.
reactomeR-HSA-1181150Signaling by NODAL
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1433617Regulation of signaling by NODAL

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD213SMR0000686503
iGMDRD52Rotenone3
iGMDRD705Nakiterpiosin3
iGMDRD353PD03259012
iGMDRD82Quiflapon3
iGMDRD356PNU-746541
iGMDRD888Compound 443
iGMDRD100Zebularine3
iGMDRD872BRD71376
iGMDRD74Idarubicin3
iGMDRD579PF7503
iGMDRD772BRD47703
iGMDRD679Bistramide A1
iGMDRD316N9-Isopropyl-olomoucine3
iGMDRD341Triacsin c3
iGMDRD201SKI II1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DAND5

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