EPHA1


Summary: This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
EPH receptor A1MIM:179610Ensembl:ENSG00000146904HGNC:HGNC:3385PA278177q34-q35

GO terms in EPHA1


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001525angiogenesis
BPIDAGO:0001954positive regulation of cell-matrix adhesion
BPIDAGO:0006469negative regulation of protein kinase activity
BPIDAGO:0007166cell surface receptor signaling pathway
BPIBAGO:0007275multicellular organism development
BPIMPGO:0008284positive regulation of cell proliferation
BPIBAGO:0009968negative regulation of signal transduction
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPIBAGO:0030154cell differentiation
BPIMPGO:0030335positive regulation of cell migration
BPIDAGO:0030336negative regulation of cell migration
BPIBAGO:0033674positive regulation of kinase activity
BPIDAGO:0034446substrate adhesion-dependent cell spreading
BPTASGO:0035019somatic stem cell population maintenance
BPIBAGO:0043066negative regulation of apoptotic process
BPIDAGO:0043087regulation of GTPase activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPIMPGO:0045766positive regulation of angiogenesis
BPIDAGO:0046777protein autophosphorylation
BPTASGO:0048013ephrin receptor signaling pathway
BPISSGO:0051496positive regulation of stress fiber assembly
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0090630activation of GTPase activity
CCIBAGO:0005737cytoplasm
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIBAGO:0043005neuron projection
CCIBAGO:0043235receptor complex
MFIDAGO:0004672protein kinase activity
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIBAGO:0005005transmembrane-ephrin receptor activity
MFIDAGO:0005005transmembrane-ephrin receptor activity
MFIEAGO:0005524ATP binding
MFIPIGO:0019901protein kinase binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding

Gene expression in normal tissue: EPHA1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EPHA1


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2892247POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928663EPHA-mediated growth cone collapse
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-3928665EPH-ephrin mediated repulsion of cells
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-452723Transcriptional regulation of pluripotent stem cells
pidepha_fwdpathwayEPHA forward signaling
netpathPathway_EGFR1EGFR1
kegghsa04360Axon guidance - Homo sapiens (human)
wikipathwaysWP3333POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD318PAC-11
iGMDRD126Tipifarnib2
iGMDRD158NSC1415403
iGMDRD512nutlin 35
iGMDRD772BRD47702
iGMDRD147Prima-11
iGMDRD394BX-7953
iGMDRD280CYTOCHALASIN B3
iGMDRD353PD03259012
iGMDRD945ML2143
iGMDRD887Compound 23 citrate1
iGMDRD329Merck602
iGMDRD152179324-69-72
iGMDRD398Sepantronium2
iGMDRD61Kinetin riboside2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPHA1

​​​​