SDHC
Summary: This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| succinate dehydrogenase complex subunit C | MIM:602413 | Ensembl:ENSG00000143252 | HGNC:HGNC:10682 | PA35607 | 1q23.3 |
Gene Categories:
CLINICALLY ACTIONABLEGO terms in SDHC
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000104 | succinate dehydrogenase activity |
| MF | IBA | GO:0008177 | succinate dehydrogenase (ubiquinone) activity |
| MF | IBA | GO:0009055 | electron transfer activity |
| MF | IEA | GO:0009055 | electron transfer activity |
| MF | IBA | GO:0020037 | heme binding |
| MF | ISS | GO:0020037 | heme binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0048039 | ubiquinone binding |
| BP | IEA | GO:0006099 | tricarboxylic acid cycle |
| BP | TAS | GO:0006099 | tricarboxylic acid cycle |
| BP | IBA | GO:0006121 | mitochondrial electron transport, succinate to ubiquinone |
| BP | IBA | GO:0006979 | response to oxidative stress |
| BP | TAS | GO:0009060 | aerobic respiration |
| BP | TAS | GO:0055114 | oxidation-reduction process |
| CC | TAS | GO:0005739 | mitochondrion |
| CC | ISS | GO:0005743 | mitochondrial inner membrane |
| CC | TAS | GO:0005743 | mitochondrial inner membrane |
| CC | IBA | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) |
| CC | ISS | GO:0005749 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) |
| CC | TAS | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0045273 | respiratory chain complex II |
Gene expression in normal tissue: SDHC
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SDHC
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-163200 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| reactome | R-HSA-611105 | Respiratory electron transport |
| reactome | R-HSA-71403 | Citric acid cycle (TCA cycle) |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| humancyc | PWY66-398 | TCA cycle |
| humancyc | PWY66-407 | superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle |
| kegg | hsa00020 | Citrate cycle (TCA cycle) - Homo sapiens (human) |
| kegg | hsa00190 | Oxidative phosphorylation - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| smpdb | SMP00057 | Citric Acid Cycle |
| smpdb | SMP00355 | Mitochondrial Electron Transport Chain |
| smpdb | SMP00546 | Congenital lactic acidosis |
| smpdb | SMP00547 | Fumarase deficiency |
| smpdb | SMP00548 | Mitochondrial complex II deficiency |
| smpdb | SMP00549 | 2-ketoglutarate dehydrogenase complex deficiency |
| smpdb | SMP00550 | Pyruvate dehydrogenase deficiency (E3) |
| smpdb | SMP00551 | Pyruvate dehydrogenase deficiency (E2) |
| smpdb | SMP00654 | Warburg Effect |
| smpdb | SMP02291 | The oncogenic action of 2-hydroxyglutarate |
| smpdb | SMP02292 | The oncogenic action of Succinate |
| smpdb | SMP02295 | The oncogenic action of Fumarate |
| smpdb | SMP02298 | Glutaminolysis and Cancer |
| smpdb | SMP02358 | The oncogenic action of L-2-hydroxyglutarate in Hydroxygluaricaciduria |
| smpdb | SMP02359 | The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria |
| wikipathways | WP111 | Electron Transport Chain |
| wikipathways | WP78 | TCA Cycle |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD6 | AM-580 | 2 |
| iGMDRD221 | Tamoxifen | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD284 | Palbociclib | 1 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD459 | RO-3306 | 1 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD67 | PENFLURIDOL | 6 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD391 | OSU-03012 | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD63 | Camptothecin | 1 |
| iGMDRD150 | RITA | 6 |
| iGMDRD276 | AS 605240 | 1 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD237 | ABT-751 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SDHC
CLASSFICATION
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