AURKA
Summary: The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| aurora kinase A | MIM:603072 | Ensembl:ENSG00000087586 | HGNC:HGNC:11393 | PA36201 | 20q13.2 |
GO terms in AURKA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0000278 | mitotic cell cycle |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | IMP | GO:0007051 | spindle organization |
| BP | IBA | GO:0007052 | mitotic spindle organization |
| BP | IEA | GO:0007057 | spindle assembly involved in female meiosis I |
| BP | IEA | GO:0007100 | mitotic centrosome separation |
| BP | IDA | GO:0009611 | response to wounding |
| BP | IEA | GO:0009948 | anterior/posterior axis specification |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0010972 | negative regulation of G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0031145 | anaphase-promoting complex-dependent catabolic process |
| BP | IMP | GO:0031647 | regulation of protein stability |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | IEA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0032465 | regulation of cytokinesis |
| BP | IEA | GO:0035404 | histone-serine phosphorylation |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0045840 | positive regulation of mitotic nuclear division |
| BP | TAS | GO:0046605 | regulation of centrosome cycle |
| BP | TAS | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0051642 | centrosome localization |
| BP | IEA | GO:0071539 | protein localization to centrosome |
| BP | IDA | GO:0097421 | liver regeneration |
| BP | IEA | GO:1900195 | positive regulation of oocyte maturation |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | IEA | GO:1990138 | neuron projection extension |
| CC | IBA | GO:0000780 | condensed nuclear chromosome, centromeric region |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005813 | centrosome |
| CC | IEA | GO:0005814 | centriole |
| CC | TAS | GO:0005819 | spindle |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005876 | spindle microtubule |
| CC | IDA | GO:0005876 | spindle microtubule |
| CC | IEA | GO:0005929 | cilium |
| CC | IDA | GO:0015630 | microtubule cytoskeleton |
| CC | TAS | GO:0030496 | midbody |
| CC | IBA | GO:0031616 | spindle pole centrosome |
| CC | IDA | GO:0031616 | spindle pole centrosome |
| CC | IBA | GO:0032133 | chromosome passenger complex |
| CC | IEA | GO:0042585 | germinal vesicle |
| CC | IEA | GO:0043203 | axon hillock |
| CC | IEA | GO:0045120 | pronucleus |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IBA | GO:0051233 | spindle midzone |
| CC | IEA | GO:0072687 | meiotic spindle |
| CC | IDA | GO:0097431 | mitotic spindle pole |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IBA | GO:0035174 | histone serine kinase activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: AURKA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in AURKA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-174178 | APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804114 | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8854050 | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
| reactome | R-HSA-8854521 | Interaction between PHLDA1 and AURKA |
| biocarta | ranmspathway | role of ran in mitotic spindle regulation |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| pid | aurora_a_pathway | Aurora A signaling |
| pid | aurora_b_pathway | Aurora B signaling |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| pid | plk1_pathway | PLK1 signaling events |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2361 | Gastric Cancer Network 1 |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD62 | Platinum | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD828 | AURK inhibitor | 6 |
| iGMDRD21 | Fluorouracil | 1 |
| iGMDRD540 | Alisertib | 1 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD160 | Cis-Platin | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD150 | RITA | 6 |
| iGMDRD148 | Pifithrin-mu | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in AURKA
CLASSFICATION
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