AURKA


Summary: The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
aurora kinase AMIM:603072Ensembl:ENSG00000087586HGNC:HGNC:11393PA3620120q13.2

GO terms in AURKA


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000086G2/M transition of mitotic cell cycle
BPTASGO:0000278mitotic cell cycle
BPIDAGO:0006468protein phosphorylation
BPTASGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPIMPGO:0007051spindle organization
BPIBAGO:0007052mitotic spindle organization
BPIEAGO:0007057spindle assembly involved in female meiosis I
BPIEAGO:0007100mitotic centrosome separation
BPIDAGO:0009611response to wounding
BPIEAGO:0009948anterior/posterior axis specification
BPTASGO:0010389regulation of G2/M transition of mitotic cell cycle
BPTASGO:0010972negative regulation of G2/M transition of mitotic cell cycle
BPTASGO:0031145anaphase-promoting complex-dependent catabolic process
BPIMPGO:0031647regulation of protein stability
BPIDAGO:0032091negative regulation of protein binding
BPIEAGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIBAGO:0032465regulation of cytokinesis
BPIEAGO:0035404histone-serine phosphorylation
BPIEAGO:0043066negative regulation of apoptotic process
BPTASGO:0045840positive regulation of mitotic nuclear division
BPTASGO:0046605regulation of centrosome cycle
BPTASGO:0046777protein autophosphorylation
BPIEAGO:0051301cell division
BPIEAGO:0051642centrosome localization
BPIEAGO:0071539protein localization to centrosome
BPIDAGO:0097421liver regeneration
BPIEAGO:1900195positive regulation of oocyte maturation
BPTASGO:1901796regulation of signal transduction by p53 class mediator
BPIEAGO:1990138neuron projection extension
CCIBAGO:0000780condensed nuclear chromosome, centromeric region
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005813centrosome
CCTASGO:0005813centrosome
CCIEAGO:0005814centriole
CCTASGO:0005819spindle
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIBAGO:0005876spindle microtubule
CCIDAGO:0005876spindle microtubule
CCIEAGO:0005929cilium
CCIDAGO:0015630microtubule cytoskeleton
CCTASGO:0030496midbody
CCIBAGO:0031616spindle pole centrosome
CCIDAGO:0031616spindle pole centrosome
CCIBAGO:0032133chromosome passenger complex
CCIEAGO:0042585germinal vesicle
CCIEAGO:0043203axon hillock
CCIEAGO:0045120pronucleus
CCIDAGO:0048471perinuclear region of cytoplasm
CCIBAGO:0051233spindle midzone
CCIEAGO:0072687meiotic spindle
CCIDAGO:0097431mitotic spindle pole
MFIDAGO:0004672protein kinase activity
MFEXPGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFTASGO:0004712protein serine/threonine/tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0019901protein kinase binding
MFIEAGO:0031625ubiquitin protein ligase binding
MFIBAGO:0035174histone serine kinase activity
MFIPIGO:0046982protein heterodimerization activity

Gene expression in normal tissue: AURKA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AURKA


DatabasePathway IDPathway Des.
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-174143APC/C-mediated degradation of cell cycle proteins
reactomeR-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M Transition
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-453274Mitotic G2-G2/M phases
reactomeR-HSA-453276Regulation of mitotic cell cycle
reactomeR-HSA-4615885SUMOylation of DNA replication proteins
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6791312TP53 Regulates Transcription of Cell Cycle Genes
reactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-69275G2/M Transition
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8854050FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
reactomeR-HSA-8854518AURKA Activation by TPX2
reactomeR-HSA-8854521Interaction between PHLDA1 and AURKA
biocartaranmspathwayrole of ran in mitotic spindle regulation
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
pidaurora_a_pathwayAurora A signaling
pidaurora_b_pathwayAurora B signaling
pidilk_pathwayIntegrin-linked kinase signaling
pidplk1_pathwayPLK1 signaling events
wikipathwaysWP1984Integrated Breast Cancer Pathway
wikipathwaysWP2361Gastric Cancer Network 1
wikipathwaysWP2593JAK-STAT
wikipathwaysWP437EGF-EGFR Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD577BIX012944
iGMDRD414MST-3123
iGMDRD68Paclitaxel1
iGMDRD62Platinum1
iGMDRD289Parthenolide1
iGMDRD255SB2250022
iGMDRD137Indisulam3
iGMDRD945ML2146
iGMDRD828AURK inhibitor6
iGMDRD21Fluorouracil1
iGMDRD540Alisertib1
iGMDRD446LY 21832405
iGMDRD341Triacsin c2
iGMDRD160Cis-Platin3
iGMDRD427ABT7373
iGMDRD116CD4372
iGMDRD150RITA6
iGMDRD148Pifithrin-mu2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AURKA

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