CSNK1E
Summary: The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| casein kinase 1 epsilon | MIM:600863 | Ensembl:ENSG00000213923 | HGNC:HGNC:2453 | PA26953 | 22q13.1 |
GO terms in CSNK1E
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | ISS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0006281 | DNA repair |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0006897 | endocytosis |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | ISS | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | ISS | GO:0032922 | circadian regulation of gene expression |
| BP | ISS | GO:0042752 | regulation of circadian rhythm |
| BP | IDA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IGI | GO:0060070 | canonical Wnt signaling pathway |
| BP | IMP | GO:0060070 | canonical Wnt signaling pathway |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | IDA | GO:1903827 | regulation of cellular protein localization |
| BP | NAS | GO:1905426 | positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation |
| BP | IC | GO:2000052 | positive regulation of non-canonical Wnt signaling pathway |
| CC | IBA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: CSNK1E
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CSNK1E
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_Wnt | Wnt |
| pid | betacatenin_deg_pathway | Degradation of beta catenin |
| pid | circadianpathway | Circadian rhythm pathway |
| pid | foxopathway | FoxO family signaling |
| pid | hedgehog_glipathway | Hedgehog signaling events mediated by Gli proteins |
| pid | p53regulationpathway | p53 pathway |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04340 | Hedgehog signaling pathway - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04392 | Hippo signaling pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04710 | Circadian rhythm - Homo sapiens (human) |
| wikipathways | WP3298 | Melatonin metabolism and effects |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4249 | Hedgehog Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201688 | WNT mediated activation of DVL |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-6791226 | Major pathway of rRNA processing in the nucleolus and cytosol |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-72312 | rRNA processing |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
| reactome | R-HSA-8868773 | rRNA processing in the nucleus and cytosol |
| reactome | R-HSA-8953854 | Metabolism of RNA |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD150 | RITA | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CSNK1E
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.