CYP24A1


Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain. In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cytochrome P450 family 24 subfamily A member 1MIM:126065Ensembl:ENSG00000019186HGNC:HGNC:2602PA2709720q13.2

GO terms in CYP24A1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005506iron ion binding
MFIEAGO:000840325-hydroxycholecalciferol-24-hydroxylase activity
MFNASGO:0016491oxidoreductase activity
MFTASGO:0020037heme binding
MFIDAGO:00303421-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
MFTASGO:00303421-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
BPIEPGO:0001649osteoblast differentiation
BPTASGO:0006766vitamin metabolic process
BPIDAGO:0033280response to vitamin D
BPTASGO:0042359vitamin D metabolic process
BPNASGO:0042369vitamin D catabolic process
BPIDAGO:0055114oxidation-reduction process
BPNASGO:0070561vitamin D receptor signaling pathway
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005739mitochondrion
CCTASGO:0005741mitochondrial outer membrane
CCIDAGO:0005886plasma membrane

Gene expression in normal tissue: CYP24A1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CYP24A1


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1643685Disease
reactomeR-HSA-196791Vitamin D (calciferol) metabolism
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211897Cytochrome P450 - arranged by substrate type
reactomeR-HSA-211916Vitamins
reactomeR-HSA-211945Phase I - Functionalization of compounds
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5579010Defective CYP24A1 causes Hypercalcemia, infantile (HCAI)
reactomeR-HSA-5579029Metabolic disorders of biological oxidation enzymes
reactomeR-HSA-5668914Diseases of metabolism
reactomeR-HSA-8957322Metabolism of steroids
wikipathwaysWP1531Vitamin D Metabolism
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP299Nuclear Receptors in Lipid Metabolism and Toxicity
wikipathwaysWP4141PI3K-AKT-mTOR - VitD3 Signalling
wikipathwaysWP43Oxidation by Cytochrome P450
wikipathwaysWP702Metapathway biotransformation Phase I and II
kegghsa00100Steroid biosynthesis - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD427ABT7373
iGMDRD144NSC953976
iGMDRD483SCH-5290743
iGMDRD781Sirolimus7
iGMDRD446LY 21832404
iGMDRD132(-)-gallocatechin-3-O-gallate6
iGMDRD103SN-383
iGMDRD474Avrainvillamide1
iGMDRD227Fatostatin A4
iGMDRD255SB2250026
iGMDRD870BRD636101
iGMDRD188Piperlongumine4
iGMDRD577BIX012942
iGMDRD780PP-302
iGMDRD366PI-1033
iGMDRD60Quinoclamine5

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYP24A1

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