EIF4E
Summary: The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eukaryotic translation initiation factor 4E | MIM:133440 | Ensembl:ENSG00000151247 | HGNC:HGNC:3287 | PA27714 | 4q23 |
GO terms in EIF4E
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0000339 | RNA cap binding |
| MF | IDA | GO:0000340 | RNA 7-methylguanosine cap binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003743 | translation initiation factor activity |
| MF | ISS | GO:0003743 | translation initiation factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0019899 | enzyme binding |
| MF | IDA | GO:0031370 | eukaryotic initiation factor 4G binding |
| MF | IDA | GO:0070491 | repressing transcription factor binding |
| BP | IMP | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0006405 | RNA export from nucleus |
| BP | TAS | GO:0006406 | mRNA export from nucleus |
| BP | TAS | GO:0006413 | translational initiation |
| BP | IDA | GO:0006417 | regulation of translation |
| BP | IMP | GO:0010507 | negative regulation of autophagy |
| BP | IEA | GO:0016032 | viral process |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| CC | IDA | GO:0000932 | P-body |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005845 | mRNA cap binding complex |
| CC | IDA | GO:0010494 | cytoplasmic stress granule |
| CC | IDA | GO:0016281 | eukaryotic translation initiation factor 4F complex |
| CC | IDA | GO:0016442 | RISC complex |
| CC | IDA | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: EIF4E
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EIF4E
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | eifpathway | eukaryotic protein translation |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | irespathway | internal ribosome entry pathway |
| biocarta | mtorpathway | mtor signaling pathway |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-156827 | L13a-mediated translational silencing of Ceruloplasmin expression |
| reactome | R-HSA-159227 | Transport of the SLBP independent Mature mRNA |
| reactome | R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA |
| reactome | R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript |
| reactome | R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-166208 | mTORC1-mediated signalling |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-429914 | Deadenylation-dependent mRNA decay |
| reactome | R-HSA-429947 | Deadenylation of mRNA |
| reactome | R-HSA-72202 | Transport of Mature Transcript to Cytoplasm |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-72613 | Eukaryotic Translation Initiation |
| reactome | R-HSA-72649 | Translation initiation complex formation |
| reactome | R-HSA-72662 | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| reactome | R-HSA-72702 | Ribosomal scanning and start codon recognition |
| reactome | R-HSA-72706 | GTP hydrolysis and joining of the 60S ribosomal subunit |
| reactome | R-HSA-72737 | Cap-dependent Translation Initiation |
| reactome | R-HSA-72766 | Translation |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-913531 | Interferon Signaling |
| smpdb | SMP00682 | Leucine Stimulation on Insulin Signaling |
| wikipathways | WP107 | Translation Factors |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| wikipathways | WP3879 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP516 | Hypertrophy Model |
| wikipathways | WP585 | Interferon type I signaling pathways |
| netpath | Pathway_Alpha6Beta4Integrin | Alpha6Beta4Integrin |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_TSLP | TSLP |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04211 | Longevity regulating pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD146 | Elesclomol | 1 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD41 | Imatinib | 1 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD381 | Rucaparib | 1 |
| iGMDRD295 | Bleomycin a2 | 1 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD450 | JNJ-26854165 | 1 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD112 | Methotrexate | 1 |
| iGMDRD160 | Cis-Platin | 1 |
| iGMDRD549 | Ibrutinib (PCI-32765) | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EIF4E
CLASSFICATION
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