GCNT2


Summary: This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glucosaminyl (N-acetyl) transferase 2 (I blood group)MIM:600429Ensembl:ENSG00000111846HGNC:HGNC:4204PA1696p24.3-p24.2

GO terms in GCNT2


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0008109N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
CCIEAGO:0000139Golgi membrane
CCNDGO:0005575cellular_component
CCIDAGO:0005794Golgi apparatus
CCTASGO:0016020membrane
CCIEAGO:0016021integral component of membrane
BPTASGO:0006024glycosaminoglycan biosynthetic process
BPIEAGO:0006486protein glycosylation
BPIMPGO:0006486protein glycosylation
BPIMPGO:0007179transforming growth factor beta receptor signaling pathway
BPTASGO:0007275multicellular organism development
BPISSGO:0008284positive regulation of cell proliferation
BPIMPGO:0010608posttranscriptional regulation of gene expression
BPIMPGO:0010718positive regulation of epithelial to mesenchymal transition
BPIMPGO:0010812negative regulation of cell-substrate adhesion
BPIMPGO:0030335positive regulation of cell migration
BPIMPGO:0034116positive regulation of heterotypic cell-cell adhesion
BPIMPGO:0036438maintenance of lens transparency
BPIMPGO:0051897positive regulation of protein kinase B signaling
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade

Gene expression in normal tissue: GCNT2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GCNT2


DatabasePathway IDPathway Des.
humancycPWY-7434terminal O-glycans residues modification
kegghsa00601Glycosphingolipid biosynthesis - lacto and neolacto series - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD494Neopeltolide1
iGMDRD142NSC748592
iGMDRD201SKI II1
iGMDRD123Isoevodiamine2
iGMDRD8024-methylfasudil2
iGMDRD513BML-2592
iGMDRD271Brefeldin A2
iGMDRD187BRD98762
iGMDRD434BMS-5369242
iGMDRD888Compound 442
iGMDRD329Merck603
iGMDRD562Navitoclax2
iGMDRD188Piperlongumine2
iGMDRD100Zebularine3
iGMDRD451Serdemetan2
iGMDRD60Quinoclamine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GCNT2

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