HOXA13


Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
homeobox A13MIM:142959Ensembl:ENSG00000106031HGNC:HGNC:5102PA293797p15.2

GO terms in HOXA13


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFTASGO:0003677DNA binding
MFIDAGO:0043565sequence-specific DNA binding
MFIMPGO:0043565sequence-specific DNA binding
BPTASGO:0001501skeletal system development
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
CCIEAGO:0005634nucleus

Gene expression in normal tissue: HOXA13

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HOXA13


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD210AC556491
iGMDRD105Triptolide2
iGMDRD289Parthenolide1
iGMDRD144NSC953972
iGMDRD318PAC-11
iGMDRD652UNC06383
iGMDRD286Nsc 6328392
iGMDRD188Piperlongumine1
iGMDRD577BIX012941
iGMDRD314Tanespimycin3
iGMDRD506Fedratinib3
iGMDRD886Compound 1541A2
iGMDRD297Austocystin D2
iGMDRD60Quinoclamine5
iGMDRD945ML2146

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HOXA13

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