KTN1
Summary: This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kinectin 1 | MIM:600381 | Ensembl:ENSG00000126777 | HGNC:HGNC:6467 | PA30256 | 14q22.3 |
GO terms in KTN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | HDA | GO:0045296 | cadherin binding |
| BP | IEA | GO:0007018 | microtubule-based movement |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | TAS | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: KTN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KTN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5625970 | RHO GTPases activate KTN1 |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD513 | BML-259 | 1 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD226 | ML006 | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD201 | SKI II | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KTN1
CLASSFICATION
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