LTBR
Summary: This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lymphotoxin beta receptor | MIM:600979 | Ensembl:ENSG00000111321 | HGNC:HGNC:6718 | PA30481 | 12p13.31 |
Gene Categories:
DRUGGABLE GENOMEGO terms in LTBR
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | IEA | GO:0043011 | myeloid dendritic cell differentiation |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0046330 | positive regulation of JNK cascade |
| BP | IEP | GO:0071260 | cellular response to mechanical stimulus |
| BP | IMP | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | TAS | GO:0005886 | plasma membrane |
Gene expression in normal tissue: LTBR
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LTBR
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA165374494 | Busulfan Pathway, Pharmacodynamics |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04672 | Intestinal immune network for IgA production - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5668541 | TNFR2 non-canonical NF-kB pathway |
| reactome | R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
| reactome | R-HSA-5676594 | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD103 | SN-38 | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD781 | Sirolimus | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LTBR
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