MPL


Summary: In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs . TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
MPL proto-oncogene, thrombopoietin receptorMIM:159530Ensembl:ENSG00000117400HGNC:HGNC:7217PA309231p34.2

GO terms in MPL


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004888transmembrane signaling receptor activity
MFIPIGO:0005515protein binding
MFIMPGO:0038164thrombopoietin receptor activity
CCIDAGO:0005794Golgi apparatus
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
CCIDAGO:0009986cell surface
CCIEAGO:0043005neuron projection
CCIEAGO:0043025neuronal cell body
BPIEAGO:0001780neutrophil homeostasis
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0008283cell proliferation
BPIEAGO:0035702monocyte homeostasis
BPIEAGO:0038163thrombopoietin-mediated signaling pathway
BPIEAGO:0050671positive regulation of lymphocyte proliferation
BPIEAGO:0070527platelet aggregation
BPIEAGO:0071456cellular response to hypoxia
BPIEAGO:1905221positive regulation of platelet formation
BPIEAGO:1990959eosinophil homeostasis
BPIEAGO:1990960basophil homeostasis

Gene expression in normal tissue: MPL

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MPL


DatabasePathway IDPathway Des.
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
biocartatpopathwaytpo signaling pathway
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-76002Platelet activation, signaling and aggregation
reactomeR-HSA-76009Platelet Aggregation (Plug Formation)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD8024-methylfasudil6
iGMDRD137Indisulam4
iGMDRD870BRD636102
iGMDRD171Pemetrexed5
iGMDRD506Fedratinib4
iGMDRD329Merck603
iGMDRD74Idarubicin3
iGMDRD887Compound 23 citrate3
iGMDRD100Zebularine5
iGMDRD451Serdemetan3
iGMDRD23Gossypol5
iGMDRD60Quinoclamine3
iGMDRD64Parbendazole3
iGMDRD932JAK inhibitor2
iGMDRD772BRD47705
iGMDRD584VER 1550085
iGMDRD607Ubistatin B5
iGMDRD126Tipifarnib3
iGMDRD781Sirolimus3
iGMDRD405PIK-753
iGMDRD193Fqi13
iGMDRD280CYTOCHALASIN B6
iGMDRD123Isoevodiamine3
iGMDRD901ELCPK3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MPL

​​​​