PBK
Summary: This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PDZ binding kinase | MIM:611210 | Ensembl:ENSG00000168078 | HGNC:HGNC:18282 | PA134925802 | 8p21.1 |
GO terms in PBK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| BP | NAS | GO:0000278 | mitotic cell cycle |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0032873 | negative regulation of stress-activated MAPK cascade |
| BP | IEA | GO:0034644 | cellular response to UV |
| BP | IEA | GO:0050728 | negative regulation of inflammatory response |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: PBK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PBK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3879 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD255 | SB225002 | 3 |
| iGMDRD109 | Gefitinib | 1 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD68 | Paclitaxel | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD562 | Navitoclax | 6 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD781 | Sirolimus | 6 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD154 | NSC23766 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PBK
CLASSFICATION
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