RNASE3


Summary: The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
ribonuclease A family member 3MIM:131398Ensembl:ENSG00000169397HGNC:HGNC:10046PA3441414q11.2

Gene Categories:

DRUGGABLE GENOME

GO terms in RNASE3


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIDAGO:0005615extracellular space
CCTASGO:0035578azurophil granule lumen
BPIDAGO:0002227innate immune response in mucosa
BPTASGO:0006401RNA catabolic process
BPTASGO:0019730antimicrobial humoral response
BPIDAGO:0019731antibacterial humoral response
BPIDAGO:0043152induction of bacterial agglutination
BPTASGO:0043312neutrophil degranulation
BPIDAGO:0045087innate immune response
BPIDAGO:0050829defense response to Gram-negative bacterium
BPIDAGO:0050830defense response to Gram-positive bacterium
BPIDAGO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide
BPIEAGO:0090501RNA phosphodiester bond hydrolysis
MFIDAGO:0001530lipopolysaccharide binding
MFIEAGO:0003676nucleic acid binding
MFIBAGO:0004519endonuclease activity
MFIBAGO:0004540ribonuclease activity
MFTASGO:0004540ribonuclease activity

Gene expression in normal tissue: RNASE3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RNASE3


DatabasePathway IDPathway Des.
kegghsa05310Asthma - Homo sapiens (human)
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-6803157Antimicrobial peptides

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD840BRAF inhibitors in BRAF mutant tumor3
iGMDRD577BIX012942
iGMDRD562Navitoclax2
iGMDRD839BRAF inhibitor3
iGMDRD188Piperlongumine1
iGMDRD300Tozasertib2
iGMDRD134Sorafenib3
iGMDRD298L-6854581
iGMDRD474Avrainvillamide1
iGMDRD68Paclitaxel1
iGMDRD318PAC-11
iGMDRD288Carboplatin1
iGMDRD434BMS-5369242
iGMDRD499PDMP3
iGMDRD61Kinetin riboside4
iGMDRD85Ursolic acid3
iGMDRD883CIL55A1
iGMDRD394BX-7952
iGMDRD889Compound 7d-cis2
iGMDRD148Pifithrin-mu3
iGMDRD126Tipifarnib3
iGMDRD483SCH-5290743
iGMDRD560MK-22063

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RNASE3

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