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AKT1

Summary: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
AKT serine/threonine kinase 1	MIM:164730	Ensembl:ENSG00000142208	HGNC:HGNC:391	PA24684	14q32.33

Gene Categories:

CLINICALLY ACTIONABLE TUMOR SUPPRESSOR KINASE SERINE THREONINE KINASE PROTEASE DRUGGABLE GENOME

GO terms in AKT1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IMP	GO:0000060	protein import into nucleus, translocation
BP	IEA	GO:0001649	osteoblast differentiation
BP	IEA	GO:0001893	maternal placenta development
BP	IDA	GO:0001934	positive regulation of protein phosphorylation
BP	IMP	GO:0001938	positive regulation of endothelial cell proliferation
BP	IEA	GO:0005978	glycogen biosynthetic process
BP	IMP	GO:0005979	regulation of glycogen biosynthetic process
BP	IEA	GO:0006006	glucose metabolic process
BP	IEA	GO:0006412	translation
BP	IEA	GO:0006417	regulation of translation
BP	TAS	GO:0006464	cellular protein modification process
BP	IDA	GO:0006468	protein phosphorylation
BP	IMP	GO:0006469	negative regulation of protein kinase activity
BP	ISS	GO:0006469	negative regulation of protein kinase activity
BP	TAS	GO:0006809	nitric oxide biosynthetic process
BP	IMP	GO:0006924	activation-induced cell death of T cells
BP	IEA	GO:0006954	inflammatory response
BP	IEA	GO:0006974	cellular response to DNA damage stimulus
BP	ISS	GO:0006979	response to oxidative stress
BP	TAS	GO:0007165	signal transduction
BP	IDA	GO:0007173	epidermal growth factor receptor signaling pathway
BP	TAS	GO:0007186	G-protein coupled receptor signaling pathway
BP	IMP	GO:0007249	I-kappaB kinase/NF-kappaB signaling
BP	IEA	GO:0007281	germ cell development
BP	IEA	GO:0007568	aging
BP	TAS	GO:0008283	cell proliferation
BP	IMP	GO:0008284	positive regulation of cell proliferation
BP	IMP	GO:0008286	insulin receptor signaling pathway
BP	IEA	GO:0008637	apoptotic mitochondrial changes
BP	IEA	GO:0008643	carbohydrate transport
BP	TAS	GO:0009408	response to heat
BP	IMP	GO:0010507	negative regulation of autophagy
BP	ISS	GO:0010628	positive regulation of gene expression
BP	IEA	GO:0010629	negative regulation of gene expression
BP	IMP	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport
BP	IEA	GO:0010763	positive regulation of fibroblast migration
BP	IEA	GO:0010765	positive regulation of sodium ion transport
BP	IMP	GO:0010907	positive regulation of glucose metabolic process
BP	IMP	GO:0010918	positive regulation of mitochondrial membrane potential
BP	IMP	GO:0010951	negative regulation of endopeptidase activity
BP	ISS	GO:0010975	regulation of neuron projection development
BP	IMP	GO:0014065	phosphatidylinositol 3-kinase signaling
BP	NAS	GO:0016242	negative regulation of macroautophagy
BP	IDA	GO:0016310	phosphorylation
BP	IEA	GO:0016567	protein ubiquitination
BP	IBA	GO:0018105	peptidyl-serine phosphorylation
BP	IDA	GO:0018105	peptidyl-serine phosphorylation
BP	TAS	GO:0018105	peptidyl-serine phosphorylation
BP	IDA	GO:0018107	peptidyl-threonine phosphorylation
BP	TAS	GO:0019221	cytokine-mediated signaling pathway
BP	IEA	GO:0021510	spinal cord development
BP	IEA	GO:0030030	cell projection organization
BP	TAS	GO:0030154	cell differentiation
BP	IEA	GO:0030163	protein catabolic process
BP	IEA	GO:0030212	hyaluronan metabolic process
BP	IDA	GO:0030307	positive regulation of cell growth
BP	IMP	GO:0030334	regulation of cell migration
BP	TAS	GO:0030334	regulation of cell migration
BP	TAS	GO:0031018	endocrine pancreas development
BP	TAS	GO:0031295	T cell costimulation
BP	IMP	GO:0031397	negative regulation of protein ubiquitination
BP	IEA	GO:0031641	regulation of myelination
BP	IDA	GO:0031659	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
BP	IEA	GO:0031663	lipopolysaccharide-mediated signaling pathway
BP	NAS	GO:0031929	TOR signaling
BP	IMP	GO:0031999	negative regulation of fatty acid beta-oxidation
BP	IDA	GO:0032079	positive regulation of endodeoxyribonuclease activity
BP	IMP	GO:0032091	negative regulation of protein binding
BP	IEA	GO:0032094	response to food
BP	TAS	GO:0032148	activation of protein kinase B activity
BP	ISS	GO:0032270	positive regulation of cellular protein metabolic process
BP	IEA	GO:0032287	peripheral nervous system myelin maintenance
BP	IEA	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BP	IMP	GO:0032869	cellular response to insulin stimulus
BP	ISS	GO:0032869	cellular response to insulin stimulus
BP	IDA	GO:0033138	positive regulation of peptidyl-serine phosphorylation
BP	IMP	GO:0034405	response to fluid shear stress
BP	IMP	GO:0034614	cellular response to reactive oxygen species
BP	IBA	GO:0035556	intracellular signal transduction
BP	IDA	GO:0035556	intracellular signal transduction
BP	IDA	GO:0035655	interleukin-18-mediated signaling pathway
BP	IEA	GO:0035924	cellular response to vascular endothelial growth factor stimulus
BP	IMP	GO:0038061	NIK/NF-kappaB signaling
BP	IEA	GO:0042593	glucose homeostasis
BP	ISS	GO:0042981	regulation of apoptotic process
BP	IEA	GO:0043065	positive regulation of apoptotic process
BP	IDA	GO:0043066	negative regulation of apoptotic process
BP	IMP	GO:0043066	negative regulation of apoptotic process
BP	ISS	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
BP	NAS	GO:0043276	anoikis
BP	TAS	GO:0043488	regulation of mRNA stability
BP	TAS	GO:0043491	protein kinase B signaling
BP	IDA	GO:0043536	positive regulation of blood vessel endothelial cell migration
BP	IMP	GO:0045429	positive regulation of nitric oxide biosynthetic process
BP	IMP	GO:0045600	positive regulation of fat cell differentiation
BP	IMP	GO:0045725	positive regulation of glycogen biosynthetic process
BP	NAS	GO:0045725	positive regulation of glycogen biosynthetic process
BP	TAS	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway
BP	IEA	GO:0045792	negative regulation of cell size
BP	IMP	GO:0045861	negative regulation of proteolysis
BP	IMP	GO:0045893	positive regulation of transcription, DNA-templated
BP	IEA	GO:0045907	positive regulation of vasoconstriction
BP	IEA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IMP	GO:0046326	positive regulation of glucose import
BP	IEA	GO:0046329	negative regulation of JNK cascade
BP	IEA	GO:0046622	positive regulation of organ growth
BP	TAS	GO:0046777	protein autophosphorylation
BP	IMP	GO:0046889	positive regulation of lipid biosynthetic process
BP	IMP	GO:0048009	insulin-like growth factor receptor signaling pathway
BP	IDA	GO:0048661	positive regulation of smooth muscle cell proliferation
BP	TAS	GO:0050999	regulation of nitric-oxide synthase activity
BP	IMP	GO:0051000	positive regulation of nitric-oxide synthase activity
BP	IDA	GO:0051091	positive regulation of DNA-binding transcription factor activity
BP	IEA	GO:0051146	striated muscle cell differentiation
BP	TAS	GO:0051186	cofactor metabolic process
BP	TAS	GO:0051898	negative regulation of protein kinase B signaling
BP	NAS	GO:0060079	excitatory postsynaptic potential
BP	ISS	GO:0060416	response to growth hormone
BP	TAS	GO:0060644	mammary gland epithelial cell differentiation
BP	IEA	GO:0060709	glycogen cell differentiation involved in embryonic placenta development
BP	IEA	GO:0060716	labyrinthine layer blood vessel development
BP	IDA	GO:0070141	response to UV-A
BP	IEA	GO:0071260	cellular response to mechanical stimulus
BP	IMP	GO:0071276	cellular response to cadmium ion
BP	IMP	GO:0071356	cellular response to tumor necrosis factor
BP	IEA	GO:0071364	cellular response to epidermal growth factor stimulus
BP	IEA	GO:0071380	cellular response to prostaglandin E stimulus
BP	IEA	GO:0071407	cellular response to organic cyclic compound
BP	IEA	GO:0071456	cellular response to hypoxia
BP	TAS	GO:0071901	negative regulation of protein serine/threonine kinase activity
BP	IMP	GO:0072655	establishment of protein localization to mitochondrion
BP	IMP	GO:0072656	maintenance of protein location in mitochondrion
BP	ISS	GO:0090201	negative regulation of release of cytochrome c from mitochondria
BP	IEA	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus
BP	IEA	GO:0097194	execution phase of apoptosis
BP	TAS	GO:0100002	negative regulation of protein kinase activity by protein phosphorylation
BP	IMP	GO:1900182	positive regulation of protein localization to nucleus
BP	NAS	GO:1901215	negative regulation of neuron death
BP	TAS	GO:1901796	regulation of signal transduction by p53 class mediator
BP	NAS	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
BP	IMP	GO:1903078	positive regulation of protein localization to plasma membrane
BP	IMP	GO:1903721	positive regulation of I-kappaB phosphorylation
BP	IMP	GO:1990090	cellular response to nerve growth factor stimulus
BP	ISS	GO:1990418	response to insulin-like growth factor stimulus
BP	IEA	GO:2000010	positive regulation of protein localization to cell surface
BP	TAS	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005737	cytoplasm
CC	ISS	GO:0005737	cytoplasm
CC	TAS	GO:0005737	cytoplasm
CC	IEA	GO:0005739	mitochondrion
CC	IEA	GO:0005819	spindle
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0005886	plasma membrane
CC	TAS	GO:0005886	plasma membrane
CC	IEA	GO:0005911	cell-cell junction
CC	IDA	GO:0015630	microtubule cytoskeleton
CC	IDA	GO:0031982	vesicle
CC	IDA	GO:0032991	protein-containing complex
CC	IEA	GO:0036064	ciliary basal body
CC	IEA	GO:0098794	postsynapse
MF	TAS	GO:0004672	protein kinase activity
MF	EXP	GO:0004674	protein serine/threonine kinase activity
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	NAS	GO:0004674	protein serine/threonine kinase activity
MF	TAS	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004712	protein serine/threonine/tyrosine kinase activity
MF	IEA	GO:0005080	protein kinase C binding
MF	IPI	GO:0005515	protein binding
MF	IC	GO:0005524	ATP binding
MF	IDA	GO:0005524	ATP binding
MF	IDA	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
MF	IDA	GO:0016301	kinase activity
MF	ISS	GO:0019899	enzyme binding
MF	IMP	GO:0030235	nitric-oxide synthase regulator activity
MF	IEA	GO:0032794	GTPase activating protein binding
MF	IPI	GO:0042802	identical protein binding
MF	IDA	GO:0042803	protein homodimerization activity
MF	IDA	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
MF	IEA	GO:0051721	protein phosphatase 2A binding
MF	IPI	GO:0071889	14-3-3 protein binding

Gene expression in normal tissue: AKT1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in AKT1

Database	Pathway ID	Pathway Des.
biocarta	achpathway	role of nicotinic acetylcholine receptors in the regulation of apoptosis
biocarta	aktpathway	akt signaling pathway
biocarta	arfpathway	tumor suppressor arf inhibits ribosomal biogenesis
biocarta	badpathway	regulation of bad phosphorylation
biocarta	bcellsurvivalpathway	b cell survival pathway
biocarta	chemicalpathway	apoptotic signaling in response to dna damage
biocarta	crebpathway	transcription factor creb and its extracellular signals
biocarta	edg1pathway	phospholipids as signalling intermediaries
biocarta	eif4pathway	regulation of eif-4e and p70s6 kinase
biocarta	erk5pathway	role of erk5 in neuronal survival pathway
biocarta	gcrpathway	corticosteroids and cardioprotection
biocarta	gleevecpathway	inhibition of cellular proliferation by gleevec
biocarta	gsk3pathway	inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocarta	hcmvpathway	human cytomegalovirus and map kinase pathways
biocarta	hdacpathway	control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk)
biocarta	her2pathway	role of erbb2 in signal transduction and oncology
biocarta	igf1mtorpathway	skeletal muscle hypertrophy is regulated via akt-mtor pathway
biocarta	il2rbpathway	il-2 receptor beta chain in t cell activation
biocarta	il4pathway	il 4 signaling pathway
biocarta	longevitypathway	the igf-1 receptor and longevity
biocarta	mtorpathway	mtor signaling pathway
biocarta	nfatpathway	nfat and hypertrophy of the heart
biocarta	no1pathway	actions of nitric oxide in the heart
biocarta	p53hypoxiapathway	hypoxia and p53 in the cardiovascular system
biocarta	ptdinspathway	phosphoinositides and their downstream targets
biocarta	ptenpathway	pten dependent cell cycle arrest and apoptosis
biocarta	raccpathway	ion channels and their functional role in vascular endothelium
biocarta	raccycdpathway	influence of ras and rho proteins on g1 to s transition
biocarta	raspathway	ras signaling pathway
biocarta	telpathway	telomeres telomerase cellular aging and immortality
biocarta	tffpathway	trefoil factors initiate mucosal healing
biocarta	trkapathway	trka receptor signaling pathway
biocarta	vegfpathway	vegf hypoxia and angiogenesis
reactome	R-HSA-109581	Apoptosis
reactome	R-HSA-109582	Hemostasis
reactome	R-HSA-109606	Intrinsic Pathway for Apoptosis
reactome	R-HSA-111447	Activation of BAD and translocation to mitochondria
reactome	R-HSA-114452	Activation of BH3-only proteins
reactome	R-HSA-1227986	Signaling by ERBB2
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-1280215	Cytokine Signaling in Immune system
reactome	R-HSA-1280218	Adaptive Immune System
reactome	R-HSA-1358803	Downregulation of ERBB2:ERBB3 signaling
reactome	R-HSA-1430728	Metabolism
reactome	R-HSA-1445148	Translocation of SLC2A4 (GLUT4) to the plasma membrane
reactome	R-HSA-1474151	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
reactome	R-HSA-157118	Signaling by NOTCH
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1640170	Cell Cycle
reactome	R-HSA-1643685	Disease
reactome	R-HSA-165159	mTOR signalling
reactome	R-HSA-168256	Immune System
reactome	R-HSA-186712	Regulation of beta-cell development
reactome	R-HSA-194138	Signaling by VEGF
reactome	R-HSA-195721	Signaling by WNT
reactome	R-HSA-196854	Metabolism of vitamins and cofactors
reactome	R-HSA-198323	AKT phosphorylates targets in the cytosol
reactome	R-HSA-198323	AKT phosphorylates targets in the cytosol
reactome	R-HSA-198693	AKT phosphorylates targets in the nucleus
reactome	R-HSA-199418	Negative regulation of the PI3K/AKT network
reactome	R-HSA-199991	Membrane Trafficking
reactome	R-HSA-199991	Membrane Trafficking
reactome	R-HSA-201681	TCF dependent signaling in response to WNT
reactome	R-HSA-202131	Metabolism of nitric oxide
reactome	R-HSA-203615	eNOS activation
reactome	R-HSA-203765	eNOS activation and regulation
reactome	R-HSA-210745	Regulation of gene expression in beta cells
reactome	R-HSA-211163	AKT-mediated inactivation of FOXO1A
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-212436	Generic Transcription Pathway
reactome	R-HSA-2219528	PI3K/AKT Signaling in Cancer
reactome	R-HSA-354192	Integrin alphaIIb beta3 signaling
reactome	R-HSA-3700989	Transcriptional Regulation by TP53
reactome	R-HSA-372790	Signaling by GPCR
reactome	R-HSA-3769402	Deactivation of the beta-catenin transactivating complex
reactome	R-HSA-388396	GPCR downstream signalling
reactome	R-HSA-388841	Costimulation by the CD28 family
reactome	R-HSA-389356	CD28 co-stimulation
reactome	R-HSA-389357	CD28 dependent PI3K/Akt signaling
reactome	R-HSA-389513	CTLA4 inhibitory signaling
reactome	R-HSA-392451	G beta:gamma signalling through PI3Kgamma
reactome	R-HSA-397795	G-protein beta:gamma signalling
reactome	R-HSA-4420097	VEGFA-VEGFR2 Pathway
reactome	R-HSA-449147	Signaling by Interleukins
reactome	R-HSA-450385	Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
reactome	R-HSA-450531	Regulation of mRNA stability by proteins that bind AU-rich elements
reactome	R-HSA-450604	KSRP (KHSRP) binds and destabilizes mRNA
reactome	R-HSA-453279	Mitotic G1-G1/S phases
reactome	R-HSA-5218920	VEGFR2 mediated vascular permeability
reactome	R-HSA-5357801	Programmed Cell Death
reactome	R-HSA-5628897	TP53 Regulates Metabolic Genes
reactome	R-HSA-5633007	Regulation of TP53 Activity
reactome	R-HSA-5653656	Vesicle-mediated transport
reactome	R-HSA-5653656	Vesicle-mediated transport
reactome	R-HSA-5663202	Diseases of signal transduction
reactome	R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer
reactome	R-HSA-6785807	Interleukin-4 and Interleukin-13 signaling
reactome	R-HSA-6804757	Regulation of TP53 Degradation
reactome	R-HSA-6804758	Regulation of TP53 Activity through Acetylation
reactome	R-HSA-6804759	Regulation of TP53 Activity through Association with Co-factors
reactome	R-HSA-6806003	Regulation of TP53 Expression and Degradation
reactome	R-HSA-6807070	PTEN Regulation
reactome	R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactome	R-HSA-69202	Cyclin E associated events during G1/S transition
reactome	R-HSA-69206	G1/S Transition
reactome	R-HSA-69242	S Phase
reactome	R-HSA-69278	Cell Cycle, Mitotic
reactome	R-HSA-69656	Cyclin A:Cdk2-associated events at S phase entry
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-73857	RNA Polymerase II Transcription
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-74160	Gene expression (Transcription)
reactome	R-HSA-76002	Platelet activation, signaling and aggregation
reactome	R-HSA-76009	Platelet Aggregation (Plug Formation)
reactome	R-HSA-8848021	Signaling by PTK6
reactome	R-HSA-8849469	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
reactome	R-HSA-8863795	Downregulation of ERBB2 signaling
reactome	R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs
reactome	R-HSA-8878166	Transcriptional regulation by RUNX2
reactome	R-HSA-8941332	RUNX2 regulates genes involved in cell migration
reactome	R-HSA-8948751	Regulation of PTEN stability and activity
reactome	R-HSA-8953854	Metabolism of RNA
reactome	R-HSA-8978934	Metabolism of cofactors
reactome	R-HSA-9006921	Integrin signaling
reactome	R-HSA-9006925	Intracellular signaling by second messengers
reactome	R-HSA-9006925	Intracellular signaling by second messengers
reactome	R-HSA-9006927	Signaling by Non-Receptor Tyrosine Kinases
reactome	R-HSA-9006934	Signaling by Receptor Tyrosine Kinases
reactome	R-HSA-9007101	Rab regulation of trafficking
reactome	R-HSA-9013694	Signaling by NOTCH4
reactome	R-HSA-9604323	Negative regulation of NOTCH4 signaling
netpath	Pathway_Alpha6Beta4Integrin	Alpha6Beta4Integrin
netpath	Pathway_AndrogenReceptor	AndrogenReceptor
netpath	Pathway_BCR	BCR
netpath	Pathway_BDNF	BDNF
netpath	Pathway_CRH	CRH
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_Fibroblast__growth__factor-1	Fibroblast growth factor-1
netpath	Pathway_Gastrin	Gastrin
netpath	Pathway_Ghrelin	Ghrelin
netpath	Pathway_IL-7	IL-7
netpath	Pathway_IL1	IL1
netpath	Pathway_IL11	IL11
netpath	Pathway_IL2	IL2
netpath	Pathway_IL3	IL3
netpath	Pathway_IL4	IL4
netpath	Pathway_IL6	IL6
netpath	Pathway_Leptin	Leptin
netpath	Pathway_Notch	Notch
netpath	Pathway_Oncostatin_M	Oncostatin_M
netpath	Pathway_Prolactin	Prolactin
netpath	Pathway_RAGE	RAGE
netpath	Pathway_TCR	TCR
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor
netpath	Pathway_TNFalpha	TNFalpha
netpath	Pathway_TSLP	TSLP
netpath	Pathway_TWEAK	TWEAK
netpath	Pathway_Wnt	Wnt
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04012	ErbB signaling pathway - Homo sapiens (human)
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)
kegg	hsa04015	Rap1 signaling pathway - Homo sapiens (human)
kegg	hsa04022	cGMP-PKG signaling pathway - Homo sapiens (human)
kegg	hsa04024	cAMP signaling pathway - Homo sapiens (human)
kegg	hsa04062	Chemokine signaling pathway - Homo sapiens (human)
kegg	hsa04066	HIF-1 signaling pathway - Homo sapiens (human)
kegg	hsa04068	FoxO signaling pathway - Homo sapiens (human)
kegg	hsa04071	Sphingolipid signaling pathway - Homo sapiens (human)
kegg	hsa04072	Phospholipase D signaling pathway - Homo sapiens (human)
kegg	hsa04140	Autophagy - animal - Homo sapiens (human)
kegg	hsa04150	mTOR signaling pathway - Homo sapiens (human)
kegg	hsa04151	PI3K-Akt signaling pathway - Homo sapiens (human)
kegg	hsa04152	AMPK signaling pathway - Homo sapiens (human)
kegg	hsa04210	Apoptosis - Homo sapiens (human)
kegg	hsa04211	Longevity regulating pathway - Homo sapiens (human)
kegg	hsa04213	Longevity regulating pathway - multiple species - Homo sapiens (human)
kegg	hsa04218	Cellular senescence - Homo sapiens (human)
kegg	hsa04261	Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegg	hsa04370	VEGF signaling pathway - Homo sapiens (human)
kegg	hsa04371	Apelin signaling pathway - Homo sapiens (human)
kegg	hsa04380	Osteoclast differentiation - Homo sapiens (human)
kegg	hsa04510	Focal adhesion - Homo sapiens (human)
kegg	hsa04550	Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegg	hsa04611	Platelet activation - Homo sapiens (human)
kegg	hsa04620	Toll-like receptor signaling pathway - Homo sapiens (human)
kegg	hsa04625	C-type lectin receptor signaling pathway - Homo sapiens (human)
kegg	hsa04630	Jak-STAT signaling pathway - Homo sapiens (human)
kegg	hsa04660	T cell receptor signaling pathway - Homo sapiens (human)
kegg	hsa04662	B cell receptor signaling pathway - Homo sapiens (human)
kegg	hsa04664	Fc epsilon RI signaling pathway - Homo sapiens (human)
kegg	hsa04666	Fc gamma R-mediated phagocytosis - Homo sapiens (human)
kegg	hsa04668	TNF signaling pathway - Homo sapiens (human)
kegg	hsa04722	Neurotrophin signaling pathway - Homo sapiens (human)
kegg	hsa04725	Cholinergic synapse - Homo sapiens (human)
kegg	hsa04728	Dopaminergic synapse - Homo sapiens (human)
kegg	hsa04910	Insulin signaling pathway - Homo sapiens (human)
kegg	hsa04914	Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegg	hsa04915	Estrogen signaling pathway - Homo sapiens (human)
kegg	hsa04917	Prolactin signaling pathway - Homo sapiens (human)
kegg	hsa04919	Thyroid hormone signaling pathway - Homo sapiens (human)
kegg	hsa04920	Adipocytokine signaling pathway - Homo sapiens (human)
kegg	hsa04922	Glucagon signaling pathway - Homo sapiens (human)
kegg	hsa04923	Regulation of lipolysis in adipocytes - Homo sapiens (human)
kegg	hsa04926	Relaxin signaling pathway - Homo sapiens (human)
kegg	hsa04931	Insulin resistance - Homo sapiens (human)
kegg	hsa04932	Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
kegg	hsa04933	AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegg	hsa04973	Carbohydrate digestion and absorption - Homo sapiens (human)
kegg	hsa05142	Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegg	hsa05145	Toxoplasmosis - Homo sapiens (human)
kegg	hsa05152	Tuberculosis - Homo sapiens (human)
kegg	hsa05160	Hepatitis C - Homo sapiens (human)
kegg	hsa05161	Hepatitis B - Homo sapiens (human)
kegg	hsa05162	Measles - Homo sapiens (human)
kegg	hsa05164	Influenza A - Homo sapiens (human)
kegg	hsa05165	Human papillomavirus infection - Homo sapiens (human)
kegg	hsa05166	HTLV-I infection - Homo sapiens (human)
kegg	hsa05167	Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegg	hsa05169	Epstein-Barr virus infection - Homo sapiens (human)
kegg	hsa05200	Pathways in cancer - Homo sapiens (human)
kegg	hsa05205	Proteoglycans in cancer - Homo sapiens (human)
kegg	hsa05210	Colorectal cancer - Homo sapiens (human)
kegg	hsa05211	Renal cell carcinoma - Homo sapiens (human)
kegg	hsa05212	Pancreatic cancer - Homo sapiens (human)
kegg	hsa05213	Endometrial cancer - Homo sapiens (human)
kegg	hsa05214	Glioma - Homo sapiens (human)
kegg	hsa05215	Prostate cancer - Homo sapiens (human)
kegg	hsa05218	Melanoma - Homo sapiens (human)
kegg	hsa05220	Chronic myeloid leukemia - Homo sapiens (human)
kegg	hsa05221	Acute myeloid leukemia - Homo sapiens (human)
kegg	hsa05222	Small cell lung cancer - Homo sapiens (human)
kegg	hsa05223	Non-small cell lung cancer - Homo sapiens (human)
kegg	hsa05224	Breast cancer - Homo sapiens (human)
kegg	hsa05225	Hepatocellular carcinoma - Homo sapiens (human)
kegg	hsa05226	Gastric cancer - Homo sapiens (human)
kegg	hsa05230	Central carbon metabolism in cancer - Homo sapiens (human)
kegg	hsa05231	Choline metabolism in cancer - Homo sapiens (human)
kegg	hsa05418	Fluid shear stress and atherosclerosis - Homo sapiens (human)
smpdb	SMP00320	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
smpdb	SMP00321	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
smpdb	SMP00358	Fc Epsilon Receptor I Signaling in Mast Cells
smpdb	SMP00391	Insulin Signalling
smpdb	SMP00682	Leucine Stimulation on Insulin Signaling
wikipathways	WP127	IL-5 Signaling Pathway
wikipathways	WP138	Androgen receptor signaling pathway
wikipathways	WP1403	AMP-activated Protein Kinase (AMPK) Signaling
wikipathways	WP1449	Regulation of toll-like receptor signaling pathway
wikipathways	WP1471	Target Of Rapamycin (TOR) Signaling
wikipathways	WP1539	Angiogenesis
wikipathways	WP1544	MicroRNAs in cardiomyocyte hypertrophy
wikipathways	WP1559	TFs Regulate miRNAs related to cardiac hypertrophy
wikipathways	WP185	Integrin-mediated Cell Adhesion
wikipathways	WP195	IL-1 signaling pathway
wikipathways	WP1982	Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathways	WP1993	Angiogenesis overview
wikipathways	WP2018	RANKL-RANK (Receptor activator of NFKB (ligand)) Signaling Pathway
wikipathways	WP2032	Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathways	WP2034	Leptin signaling pathway
wikipathways	WP2035	Follicle Stimulating Hormone (FSH) signaling pathway
wikipathways	WP2036	TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathways	WP2037	Prolactin Signaling Pathway
wikipathways	WP2038	Regulation of Microtubule Cytoskeleton
wikipathways	WP205	IL-7 Signaling Pathway
wikipathways	WP2112	IL17 signaling pathway
wikipathways	WP2203	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathways	WP2261	Signaling Pathways in Glioblastoma
wikipathways	WP23	B Cell Receptor Signaling Pathway
wikipathways	WP231	TNF alpha Signaling Pathway
wikipathways	WP2324	AGE-RAGE pathway
wikipathways	WP2332	Interleukin-11 Signaling Pathway
wikipathways	WP2355	Corticotropin-releasing hormone signaling pathway
wikipathways	WP2374	Oncostatin M Signaling Pathway
wikipathways	WP2380	Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathways	WP244	Alpha 6 Beta 4 signaling pathway
wikipathways	WP254	Apoptosis
wikipathways	WP2572	Primary Focal Segmental Glomerulosclerosis FSGS
wikipathways	WP2583	T-Cell Receptor and Co-stimulatory Signaling
wikipathways	WP2593	JAK-STAT
wikipathways	WP26	Signal Transduction of S1P Receptor
wikipathways	WP2795	Cardiac Hypertrophic Response
wikipathways	WP286	IL-3 Signaling Pathway
wikipathways	WP2864	Apoptosis-related network due to altered Notch3 in ovarian cancer
wikipathways	WP2870	Extracellular vesicle-mediated signaling in recipient cells
wikipathways	WP304	Kit receptor signaling pathway
wikipathways	WP306	Focal Adhesion
wikipathways	WP3286	Copper homeostasis
wikipathways	WP3303	Rac1-Pak1-p38-MMP-2 pathway
wikipathways	WP3584	MECP2 and Associated Rett Syndrome
wikipathways	WP363	Wnt Signaling Pathway
wikipathways	WP3639	Apoptotic Signaling Pathway
wikipathways	WP364	IL-6 signaling pathway
wikipathways	WP3646	Hepatitis C and Hepatocellular Carcinoma
wikipathways	WP3651	Pathways Affected in Adenoid Cystic Carcinoma
wikipathways	WP3658	Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathways	WP366	TGF-beta Signaling Pathway
wikipathways	WP3676	BDNF-TrkB Signaling
wikipathways	WP3680	Association Between Physico-Chemical Features and Toxicity Associated Pathways
wikipathways	WP382	MAPK Signaling Pathway
wikipathways	WP3844	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathways	WP3850	Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling
wikipathways	WP3859	TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition
wikipathways	WP3863	T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathways	WP3872	Regulation of Apoptosis by Parathyroid Hormone-related Protein
wikipathways	WP3879	4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression
wikipathways	WP3888	VEGFA-VEGFR2 Signaling Pathway
wikipathways	WP3915	Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways	WP3929	Chemokine signaling pathway
wikipathways	WP3931	ESC Pluripotency Pathways
wikipathways	WP3932	Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathways	WP3935	Leptin Insulin Overlap
wikipathways	WP395	IL-4 Signaling Pathway
wikipathways	WP3965	Lipid Metabolism Pathway
wikipathways	WP4011	Steatosis AOP
wikipathways	WP4018	Pathways in clear cell renal cell carcinoma
wikipathways	WP4066	Interleukin-4 and 13 signaling
wikipathways	WP4136	Fibrin Complement Receptor 3 Signaling Pathway
wikipathways	WP4141	PI3K-AKT-mTOR - VitD3 Signalling
wikipathways	WP4155	Endometrial cancer
wikipathways	WP4172	PI3K-Akt Signaling Pathway
wikipathways	WP4180	Ebola Virus Pathway on Host
wikipathways	WP4186	Somatroph axis (GH) and its relationship to dietary restriction and aging
wikipathways	WP4191	Caloric restriction and aging
wikipathways	WP4205	MET in type 1 papillary renal cell carcinoma
wikipathways	WP4216	Chromosomal and microsatellite instability in colorectal cancer
wikipathways	WP4217	Ebola Virus Pathway on Host
wikipathways	WP4223	Ras Signaling
wikipathways	WP4239	EMT transition in Colorectal Cancer
wikipathways	WP437	EGF-EGFR Signaling Pathway
wikipathways	WP474	Endochondral Ossification
wikipathways	WP481	Insulin Signaling
wikipathways	WP49	IL-2 Signaling Pathway
wikipathways	WP581	EPO Receptor Signaling
wikipathways	WP61	Notch Signaling Pathway
wikipathways	WP69	T-Cell antigen Receptor (TCR) Signaling Pathway
wikipathways	WP710	DNA Damage Response (only ATM dependent)
wikipathways	WP712	Estrogen signaling pathway
wikipathways	WP75	Toll-like Receptor Signaling Pathway
pid	a6b1_a6b4_integrin_pathway	a6b1 and a6b4 Integrin signaling
pid	angiopoietinreceptor_pathway	Angiopoietin receptor Tie2-mediated signaling
pid	ar_nongenomic_pathway	Nongenotropic Androgen signaling
pid	ar_pathway	Coregulation of Androgen receptor activity
pid	aurora_a_pathway	Aurora A signaling
pid	avb3_integrin_pathway	Integrins in angiogenesis
pid	bcr_5pathway	BCR signaling pathway
pid	caspase_pathway	Caspase Cascade in Apoptosis
pid	cd40_pathway	CD40/CD40L signaling
pid	cd8tcrpathway	TCR signaling in naïve CD8+ T cells
pid	ceramide_pathway	Ceramide signaling pathway
pid	cxcr3pathway	CXCR3-mediated signaling events
pid	cxcr4_pathway	CXCR4-mediated signaling events
pid	ecadherin_keratinocyte_pathway	E-cadherin signaling in keratinocytes
pid	ecadherin_nascentaj_pathway	E-cadherin signaling in the nascent adherens junction
pid	endothelinpathway	Endothelins
pid	er_nongenomic_pathway	Plasma membrane estrogen receptor signaling
pid	erbb1_downstream_pathway	ErbB1 downstream signaling
pid	erbb2erbb3pathway	ErbB2/ErbB3 signaling events
pid	faspathway	FAS (CD95) signaling pathway
pid	fcer1pathway	Fc-epsilon receptor I signaling in mast cells
pid	fgf_pathway	FGF signaling pathway
pid	foxopathway	FoxO family signaling
pid	hedgehog_2pathway	Signaling events mediated by the Hedgehog family
pid	hedgehog_glipathway	Hedgehog signaling events mediated by Gli proteins
pid	hif1_tfpathway	HIF-1-alpha transcription factor network
pid	hnf3bpathway	FOXA2 and FOXA3 transcription factor networks
pid	ifngpathway	IFN-gamma pathway
pid	igf1_pathway	IGF1 pathway
pid	il2_pi3kpathway	IL2 signaling events mediated by PI3K
pid	il4_2pathway	IL4-mediated signaling events
pid	il6_7pathway	IL6-mediated signaling events
pid	il8cxcr1_pathway	IL8- and CXCR1-mediated signaling events
pid	il8cxcr2_pathway	IL8- and CXCR2-mediated signaling events
pid	ilk_pathway	Integrin-linked kinase signaling
pid	insulin_glucose_pathway	Insulin-mediated glucose transport
pid	insulin_pathway	Insulin Pathway
pid	kitpathway	Signaling events mediated by Stem cell factor receptor (c-Kit)
pid	lymphangiogenesis_pathway	VEGFR3 signaling in lymphatic endothelium
pid	lysophospholipid_pathway	LPA receptor mediated events
pid	met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pid	mtor_4pathway	mTOR signaling pathway
pid	nephrin_neph1_pathway	Nephrin/Neph1 signaling in the kidney podocyte
pid	p53regulationpathway	p53 pathway
pid	p75ntrpathway	p75(NTR)-mediated signaling
pid	pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
pid	pi3kplctrkpathway	Trk receptor signaling mediated by PI3K and PLC-gamma
pid	ptp1bpathway	Signaling events mediated by PTP1B
pid	reelinpathway	Reelin signaling pathway
pid	reg_gr_pathway	Glucocorticoid receptor regulatory network
pid	retinoic_acid_pathway	Retinoic acid receptors-mediated signaling
pid	s1p_s1p3_pathway	S1P3 pathway
pid	smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling
pid	tcr_pathway	TCR signaling in naïve CD4+ T cells
pid	telomerasepathway	Regulation of Telomerase
pid	txa2pathway	Thromboxane A2 receptor signaling
pid	vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2
pid	vegfr1_pathway	VEGFR1 specific signals
pharmgkb	PA152241951	Celecoxib Pathway, Pharmacodynamics
pharmgkb	PA153627758	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics
pharmgkb	PA162356267	EGFR Inhibitor Pathway, Pharmacodynamics
pharmgkb	PA165959425	Pathway_PA165959425
pharmgkb	PA165959584	Sorafenib Pharmacodynamics
pharmgkb	PA2032	VEGF Signaling Pathway

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD577	BIX01294	1
iGMDRD596	Vemurafenib	1
iGMDRD119	Temsirolimus	1
iGMDRD839	BRAF inhibitor	3
iGMDRD310	Everolimus	1
iGMDRD402	AKT Inhibitor VIII	7
iGMDRD121	GMX1778	3
iGMDRD810	allosteric AKT inhibitor	4
iGMDRD983	PI3K pathway inhibitor	2
iGMDRD956	non-allosteric AKT inhibitor	2
iGMDRD289	Parthenolide	1
iGMDRD105	Triptolide	2
iGMDRD777	GSK2141795 (hydrochloride)	1
iGMDRD351	GW843682X	3
iGMDRD945	ML214	7
iGMDRD590	AZD5363	5
iGMDRD512	nutlin 3	6
iGMDRD210	AC55649	1
iGMDRD546	BMS-754807	3
iGMDRD560	MK-2206	1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in AKT1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.