BIRC3


Summary: This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
baculoviral IAP repeat containing 3MIM:601721Ensembl:ENSG00000023445HGNC:HGNC:591PA2536011q22.2

GO terms in BIRC3


Term TypeEvidence TypeGO Term IDGO Des.
MFEXPGO:0004842ubiquitin-protein transferase activity
MFIDAGO:0004842ubiquitin-protein transferase activity
MFTASGO:0004842ubiquitin-protein transferase activity
MFIPIGO:0005515protein binding
MFEXPGO:0016740transferase activity
MFIBAGO:0043027cysteine-type endopeptidase inhibitor activity involved in apoptotic process
MFIEAGO:0046872metal ion binding
MFIBAGO:0061630ubiquitin protein ligase activity
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0032991protein-containing complex
CCIEAGO:0045121membrane raft
BPIEAGO:0006915apoptotic process
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIEAGO:0007283spermatogenesis
BPTASGO:0010803regulation of tumor necrosis factor-mediated signaling pathway
BPIEAGO:0016567protein ubiquitination
BPTASGO:0016579protein deubiquitination
BPIDAGO:0031398positive regulation of protein ubiquitination
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPTASGO:0034121regulation of toll-like receptor signaling pathway
BPTASGO:0038061NIK/NF-kappaB signaling
BPTASGO:0039535regulation of RIG-I signaling pathway
BPIMPGO:0042981regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPTASGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPTASGO:0045088regulation of innate immune response
BPTASGO:0050727regulation of inflammatory response
BPIEAGO:0051291protein heterooligomerization
BPIMPGO:0060544regulation of necroptotic process
BPTASGO:0060544regulation of necroptotic process
BPIBAGO:0060546negative regulation of necroptotic process
BPTASGO:0070424regulation of nucleotide-binding oligomerization domain containing signaling pathway
BPIBAGO:0090307mitotic spindle assembly
BPIBAGO:1990001inhibition of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:2000116regulation of cysteine-type endopeptidase activity

Gene expression in normal tissue: BIRC3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BIRC3


DatabasePathway IDPathway Des.
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidcd40_pathwayCD40/CD40L signaling
pidceramide_pathwayCeramide signaling pathway
pidcmyb_pathwayC-MYB transcription factor network
pidfaspathwayFAS (CD95) signaling pathway
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidp75ntrpathwayp75(NTR)-mediated signaling
pidtnfpathwayTNF receptor signaling pathway
netpathPathway_TNFalphaTNFalpha
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04120Ubiquitin mediated proteolysis - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04215Apoptosis - multiple species - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05202Transcriptional misregulation in cancer - Homo sapiens (human)
kegghsa05222Small cell lung cancer - Homo sapiens (human)
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP254Apoptosis
wikipathwaysWP2880Glucocorticoid Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3617Photodynamic therapy-induced NF-kB survival signaling
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5213460RIPK1-mediated regulated necrosis
reactomeR-HSA-5218859Regulated Necrosis
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5357905Regulation of TNFR1 signaling
reactomeR-HSA-5357956TNFR1-induced NFkappaB signaling pathway
reactomeR-HSA-5668541TNFR2 non-canonical NF-kB pathway
reactomeR-HSA-5675482Regulation of necroptotic cell death
reactomeR-HSA-5676594TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75893TNF signaling
reactomeR-HSA-937041IKK complex recruitment mediated by RIP1
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
biocartacaspasepathwaycaspase cascade in apoptosis
biocartaceramidepathwayceramide signaling pathway
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartakeratinocytepathwaykeratinocyte differentiation
biocartamitochondriapathwayrole of mitochondria in apoptotic signaling
biocartasoddpathwaysodd/tnfr1 signaling pathway
biocartatnfr1pathwaytnfr1 signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib3
iGMDRD398Sepantronium3
iGMDRD322FK 8663
iGMDRD474Avrainvillamide3
iGMDRD121GMX17786
iGMDRD202Curcumin3
iGMDRD134Sorafenib2
iGMDRD782DC-45-A23
iGMDRD105Triptolide3
iGMDRD289Parthenolide1
iGMDRD294Batimastat3
iGMDRD318PAC-17
iGMDRD152179324-69-73
iGMDRD945ML2146
iGMDRD210AC556493
iGMDRD126Tipifarnib6
iGMDRD607Ubistatin B3
iGMDRD79Gemcitabine3
iGMDRD494Neopeltolide6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BIRC3

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