CARS


Summary: This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cysteinyl-tRNA synthetaseMIM:123859Ensembl:ENSG00000110619HGNC:HGNC:1493PA2607911p15.4

GO terms in CARS


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006418tRNA aminoacylation for protein translation
BPIBAGO:0006423cysteinyl-tRNA aminoacylation
BPIDAGO:0006423cysteinyl-tRNA aminoacylation
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
MFIMPGO:0000049tRNA binding
MFNASGO:0000049tRNA binding
MFIBAGO:0004817cysteine-tRNA ligase activity
MFIDAGO:0004817cysteine-tRNA ligase activity
MFTASGO:0004817cysteine-tRNA ligase activity
MFIPIGO:0005515protein binding
MFIBAGO:0005524ATP binding
MFIDAGO:0005524ATP binding
MFIMPGO:0042803protein homodimerization activity
MFIEAGO:0046872metal ion binding

Gene expression in normal tissue: CARS

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CARS


DatabasePathway IDPathway Des.
reactomeR-HSA-379716Cytosolic tRNA aminoacylation
reactomeR-HSA-379724tRNA Aminoacylation
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-72766Translation
humancycTRNA-CHARGING-PWYtRNA charging
kegghsa00970Aminoacyl-tRNA biosynthesis - Homo sapiens (human)
smpdbSMP00013Cysteine Metabolism
smpdbSMP00499Beta-mercaptolactate-cysteine disulfiduria
smpdbSMP00722Cystinosis, ocular nonnephropathic

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD137Indisulam3
iGMDRD260FQI-21
iGMDRD369TGX-1153
iGMDRD60Quinoclamine3
iGMDRD524ISX-93
iGMDRD399Selumetinib3
iGMDRD427ABT7373
iGMDRD523Cyanoquinoline, 113
iGMDRD151CHM-13
iGMDRD1008SR-II-138A6
iGMDRD177Teniposide3
iGMDRD123Isoevodiamine6
iGMDRD280CYTOCHALASIN B9
iGMDRD634SCHEMBL26080412
iGMDRD193Fqi13
iGMDRD351GW843682X3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CARS

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