CASP2


Summary: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
caspase 2MIM:600639Ensembl:ENSG00000106144HGNC:HGNC:1503PA260867q34

GO terms in CASP2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001554luteolysis
BPIEAGO:0003407neural retina development
BPIBAGO:0006915apoptotic process
BPNASGO:0006915apoptotic process
BPIMPGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
BPIEAGO:0007420brain development
BPIEAGO:0007568aging
BPTASGO:0008630intrinsic apoptotic signaling pathway in response to DNA damage
BPIDAGO:0016485protein processing
BPIEAGO:0035234ectopic germ cell programmed cell death
BPTASGO:0042981regulation of apoptotic process
BPIDAGO:0043065positive regulation of apoptotic process
BPNASGO:0043066negative regulation of apoptotic process
BPIEAGO:0043525positive regulation of neuron apoptotic process
BPIEPGO:0071260cellular response to mechanical stimulus
BPTASGO:0097190apoptotic signaling pathway
BPIBAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPIEAGO:0097192extrinsic apoptotic signaling pathway in absence of ligand
BPTASGO:0097194execution phase of apoptosis
BPIEAGO:2001235positive regulation of apoptotic signaling pathway
CCTASGO:0005634nucleus
CCIBAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCTASGO:0005829cytosol
CCIEAGO:0016020membrane
MFIDAGO:0004197cysteine-type endopeptidase activity
MFNASGO:0004197cysteine-type endopeptidase activity
MFIPIGO:0005515protein binding
MFISSGO:0019899enzyme binding
MFIPIGO:0019904protein domain specific binding
MFIPIGO:0042802identical protein binding
MFIBAGO:0097153cysteine-type endopeptidase activity involved in apoptotic process

Gene expression in normal tissue: CASP2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CASP2


DatabasePathway IDPathway Des.
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2371Parkinsons Disease Pathway
wikipathwaysWP254Apoptosis
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP384Apoptosis Modulation by HSP70
kegghsa04210Apoptosis - Homo sapiens (human)
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidp73pathwayp73 transcription factor network
netpathPathway_TNFalphaTNFalpha
biocartacaspasepathwaycaspase cascade in apoptosis
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartairespathwayinternal ribosome entry pathway
biocartastresspathwaytnf/stress related signaling
biocartatnfr1pathwaytnfr1 signaling pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-193704p75 NTR receptor-mediated signalling
reactomeR-HSA-204998Cell death signalling via NRAGE, NRIF and NADE
reactomeR-HSA-205025NADE modulates death signalling
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5633008TP53 Regulates Transcription of Cell Death Genes
reactomeR-HSA-6803207TP53 Regulates Transcription of Caspase Activators and Caspases
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib3
iGMDRD329Merck601
iGMDRD577BIX012941
iGMDRD138PX 122
iGMDRD137Indisulam8
iGMDRD105Triptolide2
iGMDRD705Nakiterpiosin3
iGMDRD294Batimastat2
iGMDRD226ML0062
iGMDRD318PAC-11
iGMDRD57Chloropentafluorobenzene3
iGMDRD154NSC237662
iGMDRD945ML2143
iGMDRD210AC556491
iGMDRD433Lexibulin1
iGMDRD420Leucascandrolide A2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CASP2

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