CCDC6
Summary: This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| coiled-coil domain containing 6 | MIM:601985 | Ensembl:ENSG00000108091 | HGNC:HGNC:18782 | PA134904022 | 10q21.2 |
GO terms in CCDC6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007010 | cytoskeleton organization |
| BP | ND | GO:0008150 | biological_process |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0005856 | cytoskeleton |
| MF | TAS | GO:0005200 | structural constituent of cytoskeleton |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0017124 | SH3 domain binding |
Gene expression in normal tissue: CCDC6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CCDC6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD271 | Brefeldin A | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD314 | Tanespimycin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CCDC6
CLASSFICATION
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