CLPTM1L
Summary: The protein encoded by this gene is a membrane protein whose overexpression in cisplatin-sensitive cells causes apoptosis. Polymorphisms in this gene have been reported to increase susceptibility to several cancers, including lung, pancreatic, and breast cancers. [provided by RefSeq, Nov 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CLPTM1 like | MIM:612585 | Ensembl:ENSG00000049656 | HGNC:HGNC:24308 | PA147358156 | 5p15.33 |
GO terms in CLPTM1L
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006915 | apoptotic process |
| CC | HDA | GO:0016020 | membrane |
Gene expression in normal tissue: CLPTM1L
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 4 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD150 | RITA | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 7 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD177 | Teniposide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLPTM1L
CLASSFICATION
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