CXCL9


Summary: This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
C-X-C motif chemokine ligand 9MIM:601704Ensembl:ENSG00000138755HGNC:HGNC:7098PA354954q21.1

GO terms in CXCL9


Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0006935chemotaxis
BPTASGO:0006952defense response
BPIBAGO:0006954inflammatory response
BPIBAGO:0006955immune response
BPTASGO:0006968cellular defense response
BPTASGO:0007165signal transduction
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007267cell-cell signaling
BPIEAGO:0010469regulation of signaling receptor activity
BPIBAGO:0030593neutrophil chemotaxis
BPIBAGO:0030595leukocyte chemotaxis
BPIDAGO:0042127regulation of cell proliferation
BPIDAGO:0043950positive regulation of cAMP-mediated signaling
BPIEAGO:0045663positive regulation of myoblast differentiation
BPIDAGO:0051281positive regulation of release of sequestered calcium ion into cytosol
BPIEAGO:0051607defense response to virus
BPIBAGO:0061844antimicrobial humoral immune response mediated by antimicrobial peptide
BPIBAGO:0070098chemokine-mediated signaling pathway
BPIBAGO:0071222cellular response to lipopolysaccharide
BPIEAGO:1901741positive regulation of myoblast fusion
CCTASGO:0005576extracellular region
CCIBAGO:0005615extracellular space
CCIEAGO:0009897external side of plasma membrane
MFTASGO:0005125cytokine activity
MFIPIGO:0005515protein binding
MFIBAGO:0008009chemokine activity
MFIDAGO:0008009chemokine activity
MFIBAGO:0045236CXCR chemokine receptor binding
MFIDAGO:0048248CXCR3 chemokine receptor binding

Gene expression in normal tissue: CXCL9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CXCL9


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-380108Chemokine receptors bind chemokines
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-500792GPCR ligand binding
pidcxcr3pathwayCXCR3-mediated signaling events
pidil23pathwayIL23-mediated signaling events
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP619Type II interferon signaling (IFNG)
wikipathwaysWP75Toll-like Receptor Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD138PX 123
iGMDRD474Avrainvillamide2
iGMDRD5Tyrphostin AG 14783
iGMDRD434BMS-5369243
iGMDRD105Triptolide3
iGMDRD289Parthenolide3
iGMDRD705Nakiterpiosin2
iGMDRD267Oligomycin A3
iGMDRD286Nsc 6328392
iGMDRD188Piperlongumine3
iGMDRD100Zebularine3
iGMDRD562Navitoclax2
iGMDRD330BRD41321
iGMDRD599Salermide6
iGMDRD85Ursolic acid4
iGMDRD61Kinetin riboside3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CXCL9

​​​​