FBLN5


Summary: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
fibulin 5MIM:604580Ensembl:ENSG00000140092HGNC:HGNC:3602PA2801514q32.12

Gene Categories:

DRUGGABLE GENOME

GO terms in FBLN5


Term TypeEvidence TypeGO Term IDGO Des.
MFISSGO:0005178integrin binding
MFIEAGO:0005509calcium ion binding
MFIPIGO:0005515protein binding
MFIPIGO:0008022protein C-terminus binding
MFIDAGO:0042803protein homodimerization activity
BPIEAGO:0001558regulation of cell growth
BPTASGO:0007160cell-matrix adhesion
BPTASGO:0030198extracellular matrix organization
BPISSGO:0034394protein localization to cell surface
BPIDAGO:0046903secretion
BPIMPGO:0048251elastic fiber assembly
BPISSGO:0048251elastic fiber assembly
BPISSGO:2000121regulation of removal of superoxide radicals
CCHDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCHDAGO:0005615extracellular space
CCIDAGO:0031012extracellular matrix
CCHDAGO:0062023collagen-containing extracellular matrix
CCHDAGO:0070062extracellular exosome
CCISSGO:0071953elastic fiber

Gene expression in normal tissue: FBLN5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FBLN5


DatabasePathway IDPathway Des.
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1474244Extracellular matrix organization
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-1566948Elastic fibre formation
reactomeR-HSA-2129379Molecules associated with elastic fibres
reactomeR-HSA-2129379Molecules associated with elastic fibres

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD562Navitoclax5
iGMDRD398Sepantronium2
iGMDRD23Gossypol3
iGMDRD147Prima-11
iGMDRD369TGX-1152
iGMDRD5Tyrphostin AG 14783
iGMDRD226ML0062
iGMDRD318PAC-11
iGMDRD30917AAG1
iGMDRD267Oligomycin A5
iGMDRD221Tamoxifen2
iGMDRD61Kinetin riboside2
iGMDRD152179324-69-74
iGMDRD85Ursolic acid5
iGMDRD945ML2141
iGMDRD584VER 1550082
iGMDRD512nutlin 33
iGMDRD599Salermide6
iGMDRD330BRD41321
iGMDRD427ABT7372

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FBLN5

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