HOXC13


Summary: This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
homeobox C13MIM:142976Ensembl:ENSG00000123364HGNC:HGNC:5125PA2940012q13.13

GO terms in HOXC13


Term TypeEvidence TypeGO Term IDGO Des.
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0003682chromatin binding
MFIPIGO:0005515protein binding
MFIEAGO:0043565sequence-specific DNA binding
CCIEAGO:0005634nucleus
BPIEAGO:0001942hair follicle development
BPIEAGO:0006366transcription by RNA polymerase II
BPTASGO:0009653anatomical structure morphogenesis
BPIEAGO:0009952anterior/posterior pattern specification
BPIEAGO:0035878nail development
BPIEAGO:0043587tongue morphogenesis
BPIEAGO:0045944positive regulation of transcription by RNA polymerase II

Gene expression in normal tissue: HOXC13

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HOXC13


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD366PI-1031
iGMDRD562Navitoclax6
iGMDRD577BIX012943
iGMDRD74Idarubicin3
iGMDRD730Kahalalide F3
iGMDRD188Piperlongumine3
iGMDRD444Tivantinib3
iGMDRD23Gossypol3
iGMDRD255SB2250023
iGMDRD158NSC1415403
iGMDRD434BMS-5369243
iGMDRD639YK 4-2793
iGMDRD679Bistramide A2
iGMDRD901ELCPK3
iGMDRD512nutlin 33
iGMDRD781Sirolimus3
iGMDRD424Tamatinib3
iGMDRD532Olaparib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HOXC13

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