MAPKAPK2
Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase-activated protein kinase 2 | MIM:602006 | Ensembl:ENSG00000162889 | HGNC:HGNC:6887 | PA30631 | 1q32.1 |
GO terms in MAPKAPK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0000187 | activation of MAPK activity |
| BP | IBA | GO:0002224 | toll-like receptor signaling pathway |
| BP | ISS | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006691 | leukotriene metabolic process |
| BP | IBA | GO:0006954 | inflammatory response |
| BP | ISS | GO:0006954 | inflammatory response |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IBA | GO:0007166 | cell surface receptor signaling pathway |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0032496 | response to lipopolysaccharide |
| BP | ISS | GO:0032675 | regulation of interleukin-6 production |
| BP | IDA | GO:0032680 | regulation of tumor necrosis factor production |
| BP | IBA | GO:0034097 | response to cytokine |
| BP | IDA | GO:0034097 | response to cytokine |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IMP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IEA | GO:0038066 | p38MAPK cascade |
| BP | IEA | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | ISS | GO:0044351 | macropinocytosis |
| BP | IBA | GO:0046777 | protein autophosphorylation |
| BP | IBA | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IMP | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | TAS | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IEA | GO:0048839 | inner ear development |
| BP | IDA | GO:0070935 | 3'-UTR-mediated mRNA stabilization |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IBA | GO:0009931 | calcium-dependent protein serine/threonine kinase activity |
Gene expression in normal tissue: MAPKAPK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAPKAPK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | hsp27pathway | stress induction of hsp regulation |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-167044 | Signalling to RAS |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-171007 | p38MAPK events |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187687 | Signalling to ERKs |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-199920 | CREB phosphorylation |
| reactome | R-HSA-2142691 | Synthesis of Leukotrienes (LT) and Eoxins (EX) |
| reactome | R-HSA-2142753 | Arachidonic acid metabolism |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559580 | Oxidative Stress Induced Senescence |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450302 | activated TAK1 mediates p38 MAPK activation |
| reactome | R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA |
| reactome | R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2038 | Regulation of Microtubule Cytoskeleton |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| wikipathways | WP732 | Serotonin Receptor 2 and ELK-SRF-GATA4 signaling |
| wikipathways | WP734 | Serotonin Receptor 4-6-7 and NR3C Signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| pid | vegfr1_2_pathway | Signaling events mediated by VEGFR1 and VEGFR2 |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_TNFalpha | TNFalpha |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD150 | RITA | 4 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD100 | Zebularine | 4 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAPKAPK2
CLASSFICATION
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