MAPKAPK2


Summary: This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase-activated protein kinase 2MIM:602006Ensembl:ENSG00000162889HGNC:HGNC:6887PA306311q32.1

GO terms in MAPKAPK2


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000165MAPK cascade
BPTASGO:0000165MAPK cascade
BPTASGO:0000187activation of MAPK activity
BPIBAGO:0002224toll-like receptor signaling pathway
BPISSGO:0002224toll-like receptor signaling pathway
BPTASGO:0006468protein phosphorylation
BPTASGO:0006691leukotriene metabolic process
BPIBAGO:0006954inflammatory response
BPISSGO:0006954inflammatory response
BPIMPGO:0006974cellular response to DNA damage stimulus
BPIBAGO:0007166cell surface receptor signaling pathway
BPIBAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018105peptidyl-serine phosphorylation
BPISSGO:0032496response to lipopolysaccharide
BPISSGO:0032675regulation of interleukin-6 production
BPIDAGO:0032680regulation of tumor necrosis factor production
BPIBAGO:0034097response to cytokine
BPIDAGO:0034097response to cytokine
BPIBAGO:0035556intracellular signal transduction
BPIBAGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIMPGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIEAGO:0038066p38MAPK cascade
BPIEAGO:0042535positive regulation of tumor necrosis factor biosynthetic process
BPTASGO:0043488regulation of mRNA stability
BPISSGO:0044351macropinocytosis
BPIBAGO:0046777protein autophosphorylation
BPIBAGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIMPGO:0048010vascular endothelial growth factor receptor signaling pathway
BPTASGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIEAGO:0048839inner ear development
BPIDAGO:00709353'-UTR-mediated mRNA stabilization
BPTASGO:1900034regulation of cellular response to heat
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCIDAGO:0005813centrosome
CCTASGO:0005829cytosol
CCHDAGO:0070062extracellular exosome
MFTASGO:0004672protein kinase activity
MFEXPGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004683calmodulin-dependent protein kinase activity
MFIPIGO:0005515protein binding
MFIBAGO:0005516calmodulin binding
MFIEAGO:0005524ATP binding
MFIBAGO:0009931calcium-dependent protein serine/threonine kinase activity

Gene expression in normal tissue: MAPKAPK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAPKAPK2


DatabasePathway IDPathway Des.
biocartahsp27pathwaystress induction of hsp regulation
biocartap38mapkpathwayp38 mapk signaling pathway
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-171007p38MAPK events
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-198725Nuclear Events (kinase and transcription factor activation)
reactomeR-HSA-199920CREB phosphorylation
reactomeR-HSA-2142691Synthesis of Leukotrienes (LT) and Eoxins (EX)
reactomeR-HSA-2142753Arachidonic acid metabolism
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2559580Oxidative Stress Induced Senescence
reactomeR-HSA-2559583Cellular Senescence
reactomeR-HSA-3371453Regulation of HSF1-mediated heat shock response
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinases
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-450302activated TAK1 mediates p38 MAPK activation
reactomeR-HSA-450385Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
reactomeR-HSA-450513Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
reactomeR-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elements
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-8978868Fatty acid metabolism
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
wikipathwaysWP195IL-1 signaling pathway
wikipathwaysWP2038Regulation of Microtubule Cytoskeleton
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP314Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP400p38 MAPK Signaling Pathway
wikipathwaysWP722Serotonin HTR1 Group and FOS Pathway
wikipathwaysWP732Serotonin Receptor 2 and ELK-SRF-GATA4 signaling
wikipathwaysWP734Serotonin Receptor 4-6-7 and NR3C Signaling
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
pidil2_1pathwayIL2-mediated signaling events
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
pidp38_mk2pathwayp38 signaling mediated by MAPKAP kinases
pidp38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
pidvegfr1_2_pathwaySignaling events mediated by VEGFR1 and VEGFR2
netpathPathway_BCRBCR
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
netpathPathway_TNFalphaTNFalpha

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD280CYTOCHALASIN B3
iGMDRD123Isoevodiamine2
iGMDRD634SCHEMBL26080413
iGMDRD85Ursolic acid4
iGMDRD446LY 21832404
iGMDRD193Fqi12
iGMDRD150RITA4
iGMDRD1008SR-II-138A1
iGMDRD64Parbendazole3
iGMDRD451Serdemetan3
iGMDRD356PNU-746543
iGMDRD100Zebularine4
iGMDRD188Piperlongumine2
iGMDRD562Navitoclax2
iGMDRD171Pemetrexed3
iGMDRD434BMS-5369242
iGMDRD187BRD98762
iGMDRD158NSC1415403
iGMDRD137Indisulam3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPKAPK2

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