NCOA2


Summary: The protein encoded by this gene functions as a transcriptional coactivator for nuclear hormone receptors, including steroid, thyroid, retinoid, and vitamin D receptors. The encoded protein acts as an intermediary factor for the ligand-dependent activity of these nuclear receptors, which regulate their target genes upon binding of cognate response elements. This gene has been found to be involved in translocations that result in fusions with other genes in various cancers, including the lysine acetyltransferase 6A (KAT6A) gene in acute myeloid leukemia, the ETS variant 6 (ETV6) gene in acute lymphoblastic leukemia, and the hes related family bHLH transcription factor with YRPW motif 1 (HEY1) gene in mesenchymal chondrosarcoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nuclear receptor coactivator 2MIM:601993Ensembl:ENSG00000140396HGNC:HGNC:7669PA314718q13.3

GO terms in NCOA2


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIEAGO:0005737cytoplasm
CCIDAGO:0016604nuclear body
CCIMPGO:0032991protein-containing complex
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPNASGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0010906regulation of glucose metabolic process
BPTASGO:0015721bile acid and bile salt transport
BPTASGO:0019216regulation of lipid metabolic process
BPIEAGO:0032570response to progesterone
BPIBAGO:0032870cellular response to hormone stimulus
BPISSGO:0032922circadian regulation of gene expression
BPIEAGO:0045475locomotor rhythm
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:1904017cellular response to Thyroglobulin triiodothyronine
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001162RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
MFIEAGO:0003682chromatin binding
MFISSGO:0003713transcription coactivator activity
MFNASGO:0003713transcription coactivator activity
MFIPIGO:0005515protein binding
MFIBAGO:0016922nuclear receptor binding
MFIPIGO:0016922nuclear receptor binding
MFIPIGO:0017162aryl hydrocarbon receptor binding
MFIPIGO:0019904protein domain specific binding
MFIBAGO:0030374nuclear receptor transcription coactivator activity
MFIDAGO:0030374nuclear receptor transcription coactivator activity
MFIEAGO:0030375thyroid hormone receptor coactivator activity
MFIBAGO:0035257nuclear hormone receptor binding
MFIPIGO:0035257nuclear hormone receptor binding
MFIEAGO:0046983protein dimerization activity

Gene expression in normal tissue: NCOA2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NCOA2


DatabasePathway IDPathway Des.
wikipathwaysWP138Androgen receptor signaling pathway
wikipathwaysWP2355Corticotropin-releasing hormone signaling pathway
wikipathwaysWP236Adipogenesis
wikipathwaysWP2875Constitutive Androstane Receptor Pathway
wikipathwaysWP2876Pregnane X Receptor pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP4010Liver steatosis AOP
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
pidar_pathwayCoregulation of Androgen receptor activity
pidar_tf_pathwayRegulation of Androgen receptor activity
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
pidera_genomic_pathwayValidated nuclear estrogen receptor alpha network
piderb_genomic_pathwayValidated nuclear estrogen receptor beta network
pidhif1_tfpathwayHIF-1-alpha transcription factor network
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidretinoic_acid_pathwayRetinoic acid receptors-mediated signaling
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
netpathPathway_AndrogenReceptorAndrogenReceptor
biocartappargpathwayrole of ppar-gamma coactivators in obesity and thermogenesis
biocartararrxrpathwaynuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1368082RORA activates gene expression
reactomeR-HSA-1368108BMAL1:CLOCK,NPAS2 activates circadian gene expression
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1592230Mitochondrial biogenesis
reactomeR-HSA-159418Recycling of bile acids and salts
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1655829Regulation of cholesterol biosynthesis by SREBP (SREBF)
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-192105Synthesis of bile acids and bile salts
reactomeR-HSA-193368Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
reactomeR-HSA-193807Synthesis of bile acids and bile salts via 27-hydroxycholesterol
reactomeR-HSA-194068Bile acid and bile salt metabolism
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-211859Biological oxidations
reactomeR-HSA-211897Cytochrome P450 - arranged by substrate type
reactomeR-HSA-211945Phase I - Functionalization of compounds
reactomeR-HSA-211976Endogenous sterols
reactomeR-HSA-2151201Transcriptional activation of mitochondrial biogenesis
reactomeR-HSA-2426168Activation of gene expression by SREBF (SREBP)
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3214847HATs acetylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-3899300SUMOylation of transcription cofactors
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-400253Circadian Clock
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-5625740RHO GTPases activate PKNs
reactomeR-HSA-5625886Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8939211ESR-mediated signaling
reactomeR-HSA-8957322Metabolism of steroids
reactomeR-HSA-9006931Signaling by Nuclear Receptors
reactomeR-HSA-9018519Estrogen-dependent gene expression

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD662JQ-13
iGMDRD399Selumetinib1
iGMDRD42Vorinostat3
iGMDRD322FK 8663
iGMDRD886Compound 1541A4
iGMDRD121GMX17784
iGMDRD474Avrainvillamide5
iGMDRD202Curcumin6
iGMDRD267Oligomycin A1
iGMDRD77Itraconazole3
iGMDRD6AM-5801
iGMDRD314Tanespimycin1
iGMDRD341Triacsin c2
iGMDRD330BRD41326
iGMDRD523Cyanoquinoline, 111
iGMDRD150RITA3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NCOA2

​​​​