RPS6KC1
Summary: Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribosomal protein S6 kinase C1 | MIM:617517 | Ensembl:ENSG00000136643 | HGNC:HGNC:10439 | PA34854 | 1q32.3 |
GO terms in RPS6KC1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0035091 | phosphatidylinositol binding |
| CC | IDA | GO:0005769 | early endosome |
| CC | IEA | GO:0016020 | membrane |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
Gene expression in normal tissue: RPS6KC1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS6KC1
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD100 | Zebularine | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD231 | Importazole | 2 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD123 | Isoevodiamine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPS6KC1
CLASSFICATION
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