CYSLTR2


Summary: The cysteinyl leukotrienes LTC4, LTD4, and LTE4 are important mediators of human bronchial asthma. Pharmacologic studies have determined that cysteinyl leukotrienes activate at least 2 receptors, the protein encoded by this gene and CYSLTR1. This encoded receptor is a member of the superfamily of G protein-coupled receptors. It seems to play a major role in endocrine and cardiovascular systems. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cysteinyl leukotriene receptor 2MIM:605666Ensembl:ENSG00000152207HGNC:HGNC:18274PA3851813q14.2

GO terms in CYSLTR2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001631cysteinyl leukotriene receptor activity
MFIBAGO:0004966galanin receptor activity
MFNASGO:0004974leukotriene receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0008528G-protein coupled peptide receptor activity
CCNDGO:0005575cellular_component
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
BPNASGO:0006955immune response
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway
BPIBAGO:0007218neuropeptide signaling pathway
BPIEAGO:0010942positive regulation of cell death
BPIEAGO:0045766positive regulation of angiogenesis
BPIEAGO:0061737leukotriene signaling pathway
BPIEAGO:0070374positive regulation of ERK1 and ERK2 cascade

Gene expression in normal tissue: CYSLTR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CYSLTR2


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-391903Eicosanoid ligand-binding receptors
reactomeR-HSA-391906Leukotriene receptors
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-500792GPCR ligand binding
biocartaeicosanoidpathwayeicosanoid metabolism
pidendothelinpathwayEndothelins
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
wikipathwaysWP3624Lung fibrosis
wikipathwaysWP455GPCRs, Class A Rhodopsin-like

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD481Dactolisib3
iGMDRD226ML0063
iGMDRD318PAC-11
iGMDRD885Compound 1106
iGMDRD289Parthenolide1
iGMDRD329Merck602
iGMDRD414MST-3122
iGMDRD399Selumetinib3
iGMDRD524ISX-96
iGMDRD1008SR-II-138A3
iGMDRD126Tipifarnib2
iGMDRD523Cyanoquinoline, 113
iGMDRD546BMS-7548073
iGMDRD359OSW-13
iGMDRD945ML2143
iGMDRD280CYTOCHALASIN B2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CYSLTR2

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