EDNRA


Summary: This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
endothelin receptor type AMIM:131243Ensembl:ENSG00000151617HGNC:HGNC:3179PA276174q31.22-q31.23

GO terms in EDNRA


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004435phosphatidylinositol phospholipase C activity
MFNASGO:0004962endothelin receptor activity
MFIPIGO:0005515protein binding
CCTASGO:0005886plasma membrane
CCTASGO:0005887integral component of plasma membrane
BPIEAGO:0001569branching involved in blood vessel morphogenesis
BPIEAGO:0001666response to hypoxia
BPIEAGO:0001701in utero embryonic development
BPNASGO:0006939smooth muscle contraction
BPTASGO:0007165signal transduction
BPNASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007190activation of adenylate cyclase activity
BPIEAGO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
BPTASGO:0007202activation of phospholipase C activity
BPTASGO:0007204positive regulation of cytosolic calcium ion concentration
BPIEAGO:0007507heart development
BPISSGO:0007585respiratory gaseous exchange
BPIEAGO:0008217regulation of blood pressure
BPNASGO:0008283cell proliferation
BPIEAGO:0010827regulation of glucose transmembrane transport
BPIEAGO:0014032neural crest cell development
BPIMPGO:0014824artery smooth muscle contraction
BPIMPGO:0042310vasoconstriction
BPIEAGO:0048484enteric nervous system development
BPIEAGO:0060322head development
BPIEAGO:0086100endothelin receptor signaling pathway
BPISSGO:1904659glucose transmembrane transport

Gene expression in normal tissue: EDNRA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in EDNRA


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-500792GPCR ligand binding
biocartabarrestinpathway-arrestins in gpcr desensitization
biocartabarrestinsrcpathwayroles of arrestin dependent recruitment of src kinases in gpcr signaling
biocartabarrmapkpathwayrole of -arrestins in the activation and targeting of map kinases
biocartacardiacegfpathwayrole of egf receptor transactivation by gpcrs in cardiac hypertrophy
biocartachrebppathwaychrebp regulation by carbohydrates and camp
biocartacskpathwayactivation of csk by camp-dependent protein kinase inhibits signaling through the t cell receptor
biocartagspathwayactivation of camp-dependent protein kinase pka
biocartaraccpathwayion channels and their functional role in vascular endothelium
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
pidendothelinpathwayEndothelins
pidet_egfrpathwayEGFR-dependent Endothelin signaling events
wikipathwaysWP117GPCRs, Other
wikipathwaysWP2197Endothelin Pathways
wikipathwaysWP24Peptide GPCRs
wikipathwaysWP3967miR-509-3p alteration of YAP1-ECM axis
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
wikipathwaysWP98Prostaglandin Synthesis and Regulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD6AM-5803
iGMDRD105Triptolide2
iGMDRD202Curcumin2
iGMDRD137Indisulam2
iGMDRD505Pevonedistat3
iGMDRD399Selumetinib2
iGMDRD888Compound 442
iGMDRD577BIX012941
iGMDRD560MK-22061
iGMDRD781Sirolimus1
iGMDRD210AC556491
iGMDRD387CHIR-990213
iGMDRD901ELCPK2
iGMDRD634SCHEMBL26080413
iGMDRD945ML2143
iGMDRD639YK 4-2793

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EDNRA

​​​​