GO terms in ORMDL3


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006672ceramide metabolic process
BPIMPGO:0006672ceramide metabolic process
BPTASGO:0043312neutrophil degranulation
BPIBAGO:0090156cellular sphingolipid homeostasis
BPIBAGO:1900060negative regulation of ceramide biosynthetic process
BPIMPGO:1900060negative regulation of ceramide biosynthetic process
CCIDAGO:0005783endoplasmic reticulum
CCTASGO:0005886plasma membrane
CCIEAGO:0016021integral component of membrane
CCTASGO:0030667secretory granule membrane
CCIBAGO:0035339SPOTS complex
CCIDAGO:0035339SPOTS complex
CCTASGO:0035579specific granule membrane
MFIPIGO:0005515protein binding

Gene expression in normal tissue: ORMDL3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ORMDL3


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1660661Sphingolipid de novo biosynthesis
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-428157Sphingolipid metabolism
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD255SB22500211
iGMDRD77Itraconazole5
iGMDRD68Paclitaxel2
iGMDRD434BMS-5369245
iGMDRD105Triptolide2
iGMDRD366PI-1039
iGMDRD506Fedratinib8
iGMDRD286Nsc 6328398
iGMDRD268Cerulenin2
iGMDRD60Quinoclamine2
iGMDRD330BRD41322
iGMDRD781Sirolimus1
iGMDRD494Neopeltolide2
iGMDRD144NSC953972
iGMDRD154NSC237661
iGMDRD945ML2143
iGMDRD132(-)-gallocatechin-3-O-gallate2
iGMDRD634SCHEMBL26080411

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ORMDL3

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