PARP9
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| poly(ADP-ribose) polymerase family member 9 | MIM:612065 | Ensembl:ENSG00000138496 | HGNC:HGNC:24118 | PA134870403 | 3q21.1 |
GO terms in PARP9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IGI | GO:0002230 | positive regulation of defense response to virus by host |
| BP | IMP | GO:0006302 | double-strand break repair |
| BP | IDA | GO:0006471 | protein ADP-ribosylation |
| BP | IMP | GO:0010608 | posttranscriptional regulation of gene expression |
| BP | IMP | GO:0010629 | negative regulation of gene expression |
| BP | TAS | GO:0016477 | cell migration |
| BP | TAS | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway |
| BP | IGI | GO:0035563 | positive regulation of chromatin binding |
| BP | IMP | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IDA | GO:0043086 | negative regulation of catalytic activity |
| BP | IEA | GO:0045087 | innate immune response |
| BP | IGI | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0051607 | defense response to virus |
| BP | IDA | GO:0060330 | regulation of response to interferon-gamma |
| BP | IMP | GO:0060335 | positive regulation of interferon-gamma-mediated signaling pathway |
| BP | IMP | GO:0070212 | protein poly-ADP-ribosylation |
| BP | IGI | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | IMP | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining |
| CC | IC | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0090734 | site of DNA damage |
| MF | IMP | GO:0001191 | transcriptional repressor activity, RNA polymerase II transcription factor binding |
| MF | IDA | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
| MF | IMP | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
| MF | TAS | GO:0003950 | NAD+ ADP-ribosyltransferase activity |
| MF | IDA | GO:0004857 | enzyme inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0042393 | histone binding |
| MF | IPI | GO:0044389 | ubiquitin-like protein ligase binding |
| MF | IMP | GO:0070403 | NAD+ binding |
| MF | IMP | GO:0072570 | ADP-D-ribose binding |
| MF | IPI | GO:0097677 | STAT family protein binding |
Gene expression in normal tissue: PARP9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PARP9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-196807 | Nicotinate metabolism |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-197264 | Nicotinamide salvaging |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD639 | YK 4-279 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD6 | AM-580 | 1 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD294 | Batimastat | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PARP9
CLASSFICATION
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