PI4K2B
Summary: This gene encodes a member of the type II PI4 kinase protein family. The encoded protein is primarily cytosolic and contributes to overall PI4-kinase activity along with other protein family members. This protein is involved in early T cell activation. [provided by RefSeq, Dec 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphatidylinositol 4-kinase type 2 beta | MIM:612101 | Ensembl:ENSG00000281028 | HGNC:HGNC:18215 | PA142671173 | 4p15.2 |
GO terms in PI4K2B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004430 | 1-phosphatidylinositol 4-kinase activity |
| MF | TAS | GO:0004430 | 1-phosphatidylinositol 4-kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IBA | GO:0005768 | endosome |
| CC | IBA | GO:0005802 | trans-Golgi network |
| CC | TAS | GO:0005829 | cytosol |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| BP | TAS | GO:0006661 | phosphatidylinositol biosynthetic process |
| BP | IBA | GO:0007030 | Golgi organization |
| BP | IBA | GO:0007032 | endosome organization |
| BP | IBA | GO:0046854 | phosphatidylinositol phosphorylation |
Gene expression in normal tissue: PI4K2B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PI4K2B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6352 | 3-phosphoinositide biosynthesis |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483248 | Synthesis of PIPs at the ER membrane |
| reactome | R-HSA-1483255 | PI Metabolism |
| reactome | R-HSA-1483257 | Phospholipid metabolism |
| reactome | R-HSA-1660499 | Synthesis of PIPs at the plasma membrane |
| reactome | R-HSA-1660514 | Synthesis of PIPs at the Golgi membrane |
| reactome | R-HSA-1660516 | Synthesis of PIPs at the early endosome membrane |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD901 | ELCPK | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD474 | Avrainvillamide | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD121 | GMX1778 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PI4K2B
CLASSFICATION
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