TNK1


Summary: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
tyrosine kinase non receptor 1MIM:608076Ensembl:ENSG00000174292HGNC:HGNC:11940PA3663017p13.1

GO terms in TNK1


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0006468protein phosphorylation
BPIBAGO:0007169transmembrane receptor protein tyrosine kinase signaling pathway
BPIBAGO:0030154cell differentiation
BPIEAGO:0030308negative regulation of cell growth
BPIBAGO:0038083peptidyl-tyrosine autophosphorylation
BPIBAGO:0042127regulation of cell proliferation
BPIBAGO:0045087innate immune response
BPIEAGO:0046580negative regulation of Ras protein signal transduction
BPIDAGO:0046777protein autophosphorylation
CCIDAGO:0005737cytoplasm
CCIEAGO:0005829cytosol
CCIDAGO:0016020membrane
CCIBAGO:0031234extrinsic component of cytoplasmic side of plasma membrane
MFIDAGO:0004713protein tyrosine kinase activity
MFIBAGO:0004715non-membrane spanning protein tyrosine kinase activity
MFNASGO:0004715non-membrane spanning protein tyrosine kinase activity
MFIBAGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding

Gene expression in normal tissue: TNK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TNK1


DatabasePathway IDPathway Des.
wikipathwaysWP306Focal Adhesion

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD945ML2144
iGMDRD394BX-7953
iGMDRD280CYTOCHALASIN B3
iGMDRD679Bistramide A4
iGMDRD889Compound 7d-cis3
iGMDRD772BRD47703
iGMDRD148Pifithrin-mu3
iGMDRD126Tipifarnib3
iGMDRD144NSC953976
iGMDRD577BIX012942
iGMDRD506Fedratinib3
iGMDRD188Piperlongumine6
iGMDRD353PD03259011
iGMDRD524ISX-93
iGMDRD131Erlotinib1
iGMDRD158NSC1415403
iGMDRD251ML1623
iGMDRD318PAC-14
iGMDRD870BRD636103
iGMDRD289Parthenolide2
iGMDRD434BMS-5369242

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TNK1

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