Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].

cyclin D3MIM:123834Ensembl:ENSG00000112576HGNC:HGNC:1585PA261526p21.1

GO terms in CCND3

Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity
BPIEAGO:0000122negative regulation of transcription by RNA polymerase II
BPIBAGO:0000278mitotic cell cycle
BPIDAGO:0001934positive regulation of protein phosphorylation
BPIEAGO:0007049cell cycle
BPIBAGO:0007088regulation of mitotic nuclear division
BPIEAGO:0007165signal transduction
BPIBAGO:0008284positive regulation of cell proliferation
BPIEAGO:0042098T cell proliferation
BPIEAGO:0042127regulation of cell proliferation
BPIDAGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity
BPIBAGO:0045787positive regulation of cell cycle
BPIEAGO:0046626regulation of insulin receptor signaling pathway
BPIEAGO:0051301cell division
BPIBAGO:1900087positive regulation of G1/S transition of mitotic cell cycle
CCIBAGO:0000307cyclin-dependent protein kinase holoenzyme complex
CCIDAGO:0000307cyclin-dependent protein kinase holoenzyme complex
MFIBAGO:0004672protein kinase activity
MFIEAGO:0004693cyclin-dependent protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIBAGO:0016538cyclin-dependent protein serine/threonine kinase regulator activity
MFIBAGO:0019901protein kinase binding
MFIPIGO:0019901protein kinase binding

Gene expression in normal tissue: CCND3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CCND3

DatabasePathway IDPathway Des.
biocartacellcyclepathwaycyclins and cell cycle regulation
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiation
reactomeR-HSA-453279Mitotic G1-G1/S phases
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
reactomeR-HSA-69231Cyclin D associated events in G1
reactomeR-HSA-69236G1 Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
reactomeR-HSA-8934593Regulation of RUNX1 Expression and Activity
wikipathwaysWP1530miRNA Regulation of DNA Damage Response
wikipathwaysWP1545miRNAs involved in DNA damage response
wikipathwaysWP179Cell Cycle
wikipathwaysWP2032Human Thyroid Stimulating Hormone (TSH) signaling pathway
wikipathwaysWP2446Retinoblastoma (RB) in Cancer
wikipathwaysWP306Focal Adhesion
wikipathwaysWP3287Overview of nanoparticle effects
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP428Wnt Signaling Pathway
wikipathwaysWP45G1 to S cell cycle control
wikipathwaysWP707DNA Damage Response
wikipathwaysWP710DNA Damage Response (only ATM dependent)
pidar_pathwayCoregulation of Androgen receptor activity
pide2f_pathwayE2F transcription factor network
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidrb_1pathwayRegulation of retinoblastoma protein
kegghsa04110Cell cycle - Homo sapiens (human)
kegghsa04115p53 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04390Hippo signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05165Human papillomavirus infection - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD183CDK4/6 inhibitor2
iGMDRD286Nsc 6328392
iGMDRD462OSI-906 (Linsitinib)1
iGMDRD297Austocystin D3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CCND3