GRIN2B


Summary: This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glutamate ionotropic receptor NMDA type subunit 2BMIM:138252Ensembl:ENSG00000273079HGNC:HGNC:4586PA2898012p13.1

GO terms in GRIN2B


Term TypeEvidence TypeGO Term IDGO Des.
CCISSGO:0005622intracellular
CCIBAGO:0005886plasma membrane
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCISSGO:0009986cell surface
CCISSGO:0014069postsynaptic density
CCIBAGO:0017146NMDA selective glutamate receptor complex
CCIDAGO:0017146NMDA selective glutamate receptor complex
CCTASGO:0017146NMDA selective glutamate receptor complex
CCIEAGO:0030054cell junction
CCISSGO:0043005neuron projection
CCTASGO:0045211postsynaptic membrane
CCISSGO:0097060synaptic membrane
CCIBAGO:0098839postsynaptic density membrane
BPTASGO:0000165MAPK cascade
BPTASGO:0007215glutamate receptor signaling pathway
BPTASGO:0007268chemical synaptic transmission
BPTASGO:0007275multicellular organism development
BPNASGO:0007420brain development
BPISSGO:0007611learning or memory
BPIEAGO:0019722calcium-mediated signaling
BPIEAGO:0035235ionotropic glutamate receptor signaling pathway
BPIDAGO:0045471response to ethanol
BPTASGO:0048013ephrin receptor signaling pathway
BPNASGO:0048167regulation of synaptic plasticity
BPISSGO:0051290protein heterotetramerization
BPIBAGO:0060079excitatory postsynaptic potential
BPIEAGO:0060079excitatory postsynaptic potential
BPIBAGO:0060291long-term synaptic potentiation
BPIDAGO:0097553calcium ion transmembrane import into cytosol
BPIMPGO:0097553calcium ion transmembrane import into cytosol
BPNASGO:0098976excitatory chemical synaptic transmission
BPISSGO:1901216positive regulation of neuron death
BPISSGO:1902951negative regulation of dendritic spine maintenance
BPISSGO:2001056positive regulation of cysteine-type endopeptidase activity
MFIBAGO:0004972NMDA glutamate receptor activity
MFIDAGO:0004972NMDA glutamate receptor activity
MFISSGO:0004972NMDA glutamate receptor activity
MFTASGO:0004972NMDA glutamate receptor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIEAGO:0005234extracellularly glutamate-gated ion channel activity
MFIPIGO:0005515protein binding
MFISSGO:0008270zinc ion binding
MFIDAGO:0016594glycine binding
MFISSGO:0016595glutamate binding
MFIDAGO:0022849glutamate-gated calcium ion channel activity
MFIMPGO:0022849glutamate-gated calcium ion channel activity

Gene expression in normal tissue: GRIN2B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GRIN2B


DatabasePathway IDPathway Des.
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-2682334EPH-Ephrin signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-3928662EPHB-mediated forward signaling
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-438064Post NMDA receptor activation events
reactomeR-HSA-438066Unblocking of NMDA receptor, glutamate binding and activation
reactomeR-HSA-442729CREB phosphorylation through the activation of CaMKII
reactomeR-HSA-442742CREB phosphorylation through the activation of Ras
reactomeR-HSA-442755Activation of NMDA receptor and postsynaptic events
reactomeR-HSA-442982Ras activation upon Ca2+ influx through NMDA receptor
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6794361Neurexins and neuroligins
reactomeR-HSA-6794362Protein-protein interactions at synapses
reactomeR-HSA-6794362Protein-protein interactions at synapses
reactomeR-HSA-8849932Synaptic adhesion-like molecules
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9032500Activated NTRK2 signals through FYN
biocartanos1pathwaynitric oxide signaling pathway
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04024cAMP signaling pathway - Homo sapiens (human)
kegghsa04080Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
kegghsa05030Cocaine addiction - Homo sapiens (human)
kegghsa05031Amphetamine addiction - Homo sapiens (human)
kegghsa05033Nicotine addiction - Homo sapiens (human)
kegghsa05034Alcoholism - Homo sapiens (human)
kegghsa05322Systemic lupus erythematosus - Homo sapiens (human)
piderbb4_pathwayErbB4 signaling events
pidreelinpathwayReelin signaling pathway
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP4008NO-cGMP-PKG mediated Neuroprotection
wikipathwaysWP4148Splicing factor NOVA regulated synaptic proteins
wikipathwaysWP4222Phosphodiesterases in neuronal function
wikipathwaysWP4223Ras Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD577BIX012944
iGMDRD398Sepantronium2
iGMDRD100Zebularine6
iGMDRD367Ro 28-16753
iGMDRD188Piperlongumine2
iGMDRD399Selumetinib3
iGMDRD872BRD71375
iGMDRD60Quinoclamine4
iGMDRD270Ciclosporin3
iGMDRD513BML-2592
iGMDRD294Batimastat2
iGMDRD782DC-45-A22
iGMDRD351GW843682X4
iGMDRD237ABT-7512
iGMDRD193Fqi11
iGMDRD61Kinetin riboside9
iGMDRD634SCHEMBL26080412
iGMDRD297Austocystin D2
iGMDRD123Isoevodiamine2
iGMDRD177Teniposide2
iGMDRD280CYTOCHALASIN B3
iGMDRD79Gemcitabine1
iGMDRD345Compound 10b [PMID: 11504634]2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GRIN2B

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