KAT2A


Summary: KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lysine acetyltransferase 2AMIM:602301Ensembl:ENSG00000108773HGNC:HGNC:4201PA16239266417q21.2

GO terms in KAT2A


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001756somitogenesis
BPISSGO:0001816cytokine production
BPIEAGO:0001843neural tube closure
BPTASGO:0006338chromatin remodeling
BPTASGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006366transcription by RNA polymerase II
BPISSGO:0007507heart development
BPISSGO:0007616long-term memory
BPIEAGO:0008283cell proliferation
BPIEAGO:0014070response to organic cyclic compound
BPIEAGO:0016032viral process
BPIDAGO:0016578histone deubiquitination
BPTASGO:0016579protein deubiquitination
BPIDAGO:0018393internal peptidyl-lysine acetylation
BPIEAGO:0021537telencephalon development
BPIEAGO:0022037metencephalon development
BPIEAGO:0030901midbrain development
BPIEAGO:0031346positive regulation of cell projection organization
BPIMPGO:0031647regulation of protein stability
BPIEAGO:0031667response to nutrient levels
BPIEAGO:0035066positive regulation of histone acetylation
BPIEAGO:0035264multicellular organism growth
BPIEAGO:0035948positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
BPIDAGO:0043966histone H3 acetylation
BPIEAGO:0043983histone H4-K12 acetylation
BPIEAGO:0044154histone H3-K14 acetylation
BPISSGO:0045589regulation of regulatory T cell differentiation
BPTASGO:0045815positive regulation of gene expression, epigenetic
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046600negative regulation of centriole replication
BPISSGO:0048167regulation of synaptic plasticity
BPIEAGO:0048312intracellular distribution of mitochondria
BPISSGO:0050863regulation of T cell activation
BPIEAGO:0055007cardiac muscle cell differentiation
BPISSGO:0060173limb development
BPIEAGO:0071356cellular response to tumor necrosis factor
BPIEAGO:0071929alpha-tubulin acetylation
BPIDAGO:0106077histone succinylation
BPIEAGO:1990090cellular response to nerve growth factor stimulus
BPIEAGO:2000679positive regulation of transcription regulatory region DNA binding
CCIEAGO:0000790nuclear chromatin
CCHDAGO:0005615extracellular space
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005671Ada2/Gcn5/Ada3 transcription activator complex
CCIDAGO:0005813centrosome
CCIDAGO:0030914STAGA complex
CCIDAGO:0033276transcription factor TFTC complex
CCIDAGO:0045252oxoglutarate dehydrogenase complex
CCIEAGO:0072686mitotic spindle
MFIDAGO:0003682chromatin binding
MFIDAGO:0003713transcription coactivator activity
MFIDAGO:0004402histone acetyltransferase activity
MFIDAGO:0004402histone acetyltransferase activity
MFTASGO:0004402histone acetyltransferase activity
MFIPIGO:0005515protein binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0010484H3 histone acetyltransferase activity
MFIEAGO:0019903protein phosphatase binding
MFTASGO:0036459thiol-dependent ubiquitinyl hydrolase activity
MFIPIGO:0042826histone deacetylase binding
MFIEAGO:0043997histone acetyltransferase activity (H4-K12 specific)
MFIDAGO:0061733peptide-lysine-N-acetyltransferase activity
MFIDAGO:0106078histone succinyltransferase activity

Gene expression in normal tissue: KAT2A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in KAT2A


DatabasePathway IDPathway Des.
wikipathwaysWP268Notch Signaling Pathway
wikipathwaysWP4242Notch Signaling Pathway
pide2f_pathwayE2F transcription factor network
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
pidmyc_pathwayC-MYC pathway
pidp53downstreampathwayDirect p53 effectors
pidsmad2_3nuclearpathwayRegulation of nuclear SMAD2/3 signaling
kegghsa04330Notch signaling pathway - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-186712Regulation of beta-cell development
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912408Pre-NOTCH Transcription and Translation
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-1912422Pre-NOTCH Expression and Processing
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-210744Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
reactomeR-HSA-212165Epigenetic regulation of gene expression
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-2122947NOTCH1 Intracellular Domain Regulates Transcription
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-2644602Signaling by NOTCH1 PEST Domain Mutants in Cancer
reactomeR-HSA-2644603Signaling by NOTCH1 in Cancer
reactomeR-HSA-2644606Constitutive Signaling by NOTCH1 PEST Domain Mutants
reactomeR-HSA-2894858Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
reactomeR-HSA-2894862Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
reactomeR-HSA-3214847HATs acetylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-350054Notch-HLH transcription pathway
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5250913Positive epigenetic regulation of rRNA expression
reactomeR-HSA-5250924B-WICH complex positively regulates rRNA expression
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-73762RNA Polymerase I Transcription Initiation
reactomeR-HSA-73854RNA Polymerase I Promoter Clearance
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73864RNA Polymerase I Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8878159Transcriptional regulation by RUNX3
reactomeR-HSA-8941856RUNX3 regulates NOTCH signaling
reactomeR-HSA-8941856RUNX3 regulates NOTCH signaling
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9012852Signaling by NOTCH3
reactomeR-HSA-9013508NOTCH3 Intracellular Domain Regulates Transcription
reactomeR-HSA-9013508NOTCH3 Intracellular Domain Regulates Transcription
reactomeR-HSA-9013694Signaling by NOTCH4
reactomeR-HSA-9013695NOTCH4 Intracellular Domain Regulates Transcription

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD160Cis-Platin1
iGMDRD321Daporinad1
iGMDRD614Dabrafenib1
iGMDRD116CD4371
iGMDRD50Cytarabine2
iGMDRD382CEP-7011
iGMDRD564GSK-6503941
iGMDRD177Teniposide1
iGMDRD435BI-25361
iGMDRD317CCT 0181592
iGMDRD351GW843682X2
iGMDRD88AICA ribonucleotide1
iGMDRD68Paclitaxel1
iGMDRD504Obatoclax1
iGMDRD158NSC1415402
iGMDRD121GMX17781
iGMDRD293Bleomycin1
iGMDRD173Epothilone B2
iGMDRD505Pevonedistat1
iGMDRD300Tozasertib2
iGMDRD42Vorinostat1
iGMDRD421AZD77622
iGMDRD377Compound 1b1
iGMDRD63Camptothecin2
iGMDRD403BAY 61-36061
iGMDRD489GSK-4613641
iGMDRD126Tipifarnib1
iGMDRD112Methotrexate1
iGMDRD1008SR-II-138A1
iGMDRD394BX-7951
iGMDRD378ZM-4474392
iGMDRD253Vincaleukoblastine2
iGMDRD890CR.1.31B1
iGMDRD66Doxorubicin2
iGMDRD700AUY9221
iGMDRD94Narciclasine1
iGMDRD640CAY106181
iGMDRD100Zebularine1
iGMDRD146Elesclomol1
iGMDRD391OSU-030121

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KAT2A

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