PDGFB
Summary: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| platelet derived growth factor subunit B | MIM:190040 | Ensembl:ENSG00000100311 | HGNC:HGNC:8800 | PA33145 | 22q13.1 |
GO terms in PDGFB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | NAS | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005796 | Golgi lumen |
| CC | IDA | GO:0009986 | cell surface |
| CC | ISS | GO:0016323 | basolateral plasma membrane |
| CC | TAS | GO:0031093 | platelet alpha granule lumen |
| CC | HDA | GO:0062023 | collagen-containing extracellular matrix |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0001892 | embryonic placenta development |
| BP | IDA | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IDA | GO:0002548 | monocyte chemotaxis |
| BP | TAS | GO:0002576 | platelet degranulation |
| BP | ISS | GO:0003104 | positive regulation of glomerular filtration |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0007507 | heart development |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0009611 | response to wounding |
| BP | NAS | GO:0009611 | response to wounding |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IDA | GO:0010512 | negative regulation of phosphatidylinositol biosynthetic process |
| BP | IDA | GO:0010544 | negative regulation of platelet activation |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010629 | negative regulation of gene expression |
| BP | IBA | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IDA | GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling |
| BP | IDA | GO:0014911 | positive regulation of smooth muscle cell migration |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0030097 | hemopoiesis |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IBA | GO:0030335 | positive regulation of cell migration |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IBA | GO:0031954 | positive regulation of protein autophosphorylation |
| BP | IDA | GO:0031954 | positive regulation of protein autophosphorylation |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | IDA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0032148 | activation of protein kinase B activity |
| BP | IDA | GO:0035655 | interleukin-18-mediated signaling pathway |
| BP | IDA | GO:0035793 | positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway |
| BP | ISS | GO:0038001 | paracrine signaling |
| BP | IBA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IDA | GO:0043406 | positive regulation of MAP kinase activity |
| BP | IMP | GO:0043410 | positive regulation of MAPK cascade |
| BP | IDA | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IDA | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| BP | IDA | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IDA | GO:0045840 | positive regulation of mitotic nuclear division |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0046854 | phosphatidylinositol phosphorylation |
| BP | IBA | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | IDA | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| BP | IDA | GO:0048146 | positive regulation of fibroblast proliferation |
| BP | IDA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | IDA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0050918 | positive chemotaxis |
| BP | IDA | GO:0050921 | positive regulation of chemotaxis |
| BP | IEA | GO:0051781 | positive regulation of cell division |
| BP | TAS | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IDA | GO:0060326 | cell chemotaxis |
| BP | IDA | GO:0061098 | positive regulation of protein tyrosine kinase activity |
| BP | IBA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IDA | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IMP | GO:0070528 | protein kinase C signaling |
| BP | IDA | GO:0071363 | cellular response to growth factor stimulus |
| BP | ISS | GO:0071506 | cellular response to mycophenolic acid |
| BP | IDA | GO:0072126 | positive regulation of glomerular mesangial cell proliferation |
| BP | ISS | GO:0072255 | metanephric glomerular mesangial cell development |
| BP | IMP | GO:0072593 | reactive oxygen species metabolic process |
| BP | IDA | GO:0090280 | positive regulation of calcium ion import |
| BP | IDA | GO:1900127 | positive regulation of hyaluronan biosynthetic process |
| BP | IDA | GO:1902894 | negative regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IDA | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| BP | IDA | GO:1904707 | positive regulation of vascular smooth muscle cell proliferation |
| BP | IDA | GO:1904754 | positive regulation of vascular associated smooth muscle cell migration |
| BP | IDA | GO:1905064 | negative regulation of vascular smooth muscle cell differentiation |
| BP | IDA | GO:1905176 | positive regulation of vascular smooth muscle cell dedifferentiation |
| BP | IDA | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| BP | IDA | GO:2000573 | positive regulation of DNA biosynthetic process |
| BP | IDA | GO:2000591 | positive regulation of metanephric mesenchymal cell migration |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | IBA | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IDA | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IPI | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | NAS | GO:0005161 | platelet-derived growth factor receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005518 | collagen binding |
| MF | IDA | GO:0008083 | growth factor activity |
| MF | IDA | GO:0016176 | superoxide-generating NADPH oxidase activator activity |
| MF | IDA | GO:0042056 | chemoattractant activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | TAS | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity |
| MF | IPI | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0048407 | platelet-derived growth factor binding |
| MF | IBA | GO:0070851 | growth factor receptor binding |
Gene expression in normal tissue: PDGFB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDGFB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | dbpbpathway | transcriptional activation of dbpb from mrna |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114608 | Platelet degranulation |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-2219530 | Constitutive Signaling by Aberrant PI3K in Cancer |
| reactome | R-HSA-3000171 | Non-integrin membrane-ECM interactions |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-76005 | Response to elevated platelet cytosolic Ca2+ |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| wikipathways | WP12 | Osteoclast Signaling |
| wikipathways | WP1539 | Angiogenesis |
| wikipathways | WP2526 | PDGF Pathway |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP322 | Osteoblast Signaling |
| wikipathways | WP3624 | Lung fibrosis |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4241 | Type 2 papillary renal cell carcinoma |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| pid | integrin3_pathway | Beta3 integrin cell surface interactions |
| pid | nectin_pathway | Nectin adhesion pathway |
| pid | pdgf_pathway | PDGF receptor signaling network |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | s1p_s1p1_pathway | S1P1 pathway |
| pid | s1p_s1p3_pathway | S1P3 pathway |
| pid | shp2_pathway | SHP2 signaling |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05211 | Renal cell carcinoma - Homo sapiens (human) |
| kegg | hsa05214 | Glioma - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05218 | Melanoma - Homo sapiens (human) |
| kegg | hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 6 |
| iGMDRD474 | Avrainvillamide | 4 |
| iGMDRD255 | SB225002 | 6 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD409 | Saracatinib | 1 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD150 | RITA | 1 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDGFB
CLASSFICATION
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