PRKCZ
Summary: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase C zeta | MIM:176982 | Ensembl:ENSG00000067606 | HGNC:HGNC:9412 | PA33775 | 1p36.33 |
GO terms in PRKCZ
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004697 | protein kinase C activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0015459 | potassium channel regulator activity |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0019904 | protein domain specific binding |
| MF | IEA | GO:0043274 | phospholipase binding |
| MF | IC | GO:0043560 | insulin receptor substrate binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IEA | GO:0071889 | 14-3-3 protein binding |
| BP | IEA | GO:0000226 | microtubule cytoskeleton organization |
| BP | IEA | GO:0001954 | positive regulation of cell-matrix adhesion |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IEA | GO:0007616 | long-term memory |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008286 | insulin receptor signaling pathway |
| BP | IEA | GO:0016477 | cell migration |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0030010 | establishment of cell polarity |
| BP | IMP | GO:0031333 | negative regulation of protein complex assembly |
| BP | IEA | GO:0031532 | actin cytoskeleton reorganization |
| BP | IEA | GO:0031584 | activation of phospholipase D activity |
| BP | IEA | GO:0032148 | activation of protein kinase B activity |
| BP | ISS | GO:0032753 | positive regulation of interleukin-4 production |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0045630 | positive regulation of T-helper 2 cell differentiation |
| BP | IEA | GO:0046326 | positive regulation of glucose import |
| BP | IMP | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | ISS | GO:0046628 | positive regulation of insulin receptor signaling pathway |
| BP | IEA | GO:0047496 | vesicle transport along microtubule |
| BP | IMP | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | IEA | GO:0051346 | negative regulation of hydrolase activity |
| BP | IEA | GO:0051899 | membrane depolarization |
| BP | IEA | GO:0060081 | membrane hyperpolarization |
| BP | ISS | GO:0060291 | long-term synaptic potentiation |
| BP | IMP | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IEA | GO:0070528 | protein kinase C signaling |
| BP | IEA | GO:0072659 | protein localization to plasma membrane |
| BP | IEA | GO:1990138 | neuron projection extension |
| BP | ISS | GO:2000463 | positive regulation of excitatory postsynaptic potential |
| BP | ISS | GO:2000553 | positive regulation of T-helper 2 cell cytokine production |
| BP | ISS | GO:2000664 | positive regulation of interleukin-5 secretion |
| BP | ISS | GO:2000667 | positive regulation of interleukin-13 secretion |
| BP | ISS | GO:2001181 | positive regulation of interleukin-10 secretion |
| CC | IEA | GO:0005635 | nuclear envelope |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005768 | endosome |
| CC | IEA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005911 | cell-cell junction |
| CC | IEA | GO:0005923 | bicellular tight junction |
| CC | TAS | GO:0016020 | membrane |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0016363 | nuclear matrix |
| CC | TAS | GO:0030054 | cell junction |
| CC | IEA | GO:0031252 | cell leading edge |
| CC | IEA | GO:0031941 | filamentous actin |
| CC | IDA | GO:0031982 | vesicle |
| CC | IEA | GO:0035748 | myelin sheath abaxonal region |
| CC | IEA | GO:0043203 | axon hillock |
| CC | IEA | GO:0045121 | membrane raft |
| CC | IEA | GO:0045179 | apical cortex |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: PRKCZ
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKCZ
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1584 | Type II diabetes mellitus |
| wikipathways | WP195 | IL-1 signaling pathway |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP289 | Myometrial Relaxation and Contraction Pathways |
| wikipathways | WP35 | G Protein Signaling Pathways |
| wikipathways | WP3656 | Interleukin-1 Induced Activation of NF-kappa-B |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3987 | HDAC6 interactions |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP3998 | Prader-Willi and Angelman Syndrome |
| wikipathways | WP4148 | Splicing factor NOVA regulated synaptic proteins |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP536 | Calcium Regulation in the Cardiac Cell |
| smpdb | SMP00320 | Intracellular Signalling Through Adenosine Receptor A2a and Adenosine |
| smpdb | SMP00321 | Intracellular Signalling Through Adenosine Receptor A2b and Adenosine |
| pid | cdc42_pathway | CDC42 signaling events |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | igf1_pathway | IGF1 pathway |
| pid | il1pathway | IL1-mediated signaling events |
| pid | il2_pi3kpathway | IL2 signaling events mediated by PI3K |
| pid | insulin_glucose_pathway | Insulin-mediated glucose transport |
| pid | insulin_pathway | Insulin Pathway |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | nephrin_neph1_pathway | Nephrin/Neph1 signaling in the kidney podocyte |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | ras_pathway | Regulation of Ras family activation |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | tnfpathway | TNF receptor signaling pathway |
| pid | trkrpathway | Neurotrophic factor-mediated Trk receptor signaling |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04930 | Type II diabetes mellitus - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| biocarta | ptdinspathway | phosphoinositides and their downstream targets |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-114604 | GPVI-mediated activation cascade |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-170834 | Signaling by TGF-beta Receptor Complex |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| reactome | R-HSA-2173791 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5218921 | VEGFR2 mediated cell proliferation |
| reactome | R-HSA-76002 | Platelet activation, signaling and aggregation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD579 | PF750 | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD237 | ABT-751 | 4 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD441 | TW 37 | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD67 | PENFLURIDOL | 4 |
| iGMDRD322 | FK 866 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKCZ
CLASSFICATION
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