TAOK2


Summary: This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TAO kinase 2MIM:613199Ensembl:ENSG00000149930HGNC:HGNC:16835PA13490796416p11.2

GO terms in TAOK2


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFNASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004709MAP kinase kinase kinase activity
MFNASGO:0004709MAP kinase kinase kinase activity
MFIEAGO:0005524ATP binding
MFIPIGO:0031434mitogen-activated protein kinase kinase binding
MFIPIGO:0038191neuropilin binding
BPIBAGO:0000186activation of MAPKK activity
BPIDAGO:0000186activation of MAPKK activity
BPTASGO:0000187activation of MAPK activity
BPNASGO:0001558regulation of cell growth
BPNASGO:0006612protein targeting to membrane
BPNASGO:0006915apoptotic process
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIMPGO:0007095mitotic G2 DNA damage checkpoint
BPIBAGO:0007346regulation of mitotic cell cycle
BPIGIGO:0007409axonogenesis
BPISSGO:0007409axonogenesis
BPIDAGO:0008360regulation of cell shape
BPNASGO:0016477cell migration
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIDAGO:0030036actin cytoskeleton organization
BPTASGO:0031954positive regulation of protein autophosphorylation
BPIBAGO:0032147activation of protein kinase activity
BPTASGO:0032147activation of protein kinase activity
BPIMPGO:0032874positive regulation of stress-activated MAPK cascade
BPISSGO:0032956regulation of actin cytoskeleton organization
BPIDAGO:0046330positive regulation of JNK cascade
BPISSGO:0046330positive regulation of JNK cascade
BPTASGO:0046777protein autophosphorylation
BPIDAGO:0048041focal adhesion assembly
BPIDAGO:0051403stress-activated MAPK cascade
BPISSGO:0150019basal dendrite morphogenesis
BPISSGO:0150020basal dendrite arborization
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005730nucleolus
CCIBAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCISSGO:0015629actin cytoskeleton
CCIEAGO:0016021integral component of membrane
CCISSGO:0030424axon
CCIEAGO:0030659cytoplasmic vesicle membrane
CCIDAGO:0031410cytoplasmic vesicle
CCISSGO:0043005neuron projection
CCIDAGO:0043235receptor complex
CCISSGO:0044294dendritic growth cone
CCISSGO:0044295axonal growth cone

Gene expression in normal tissue: TAOK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TAOK2


DatabasePathway IDPathway Des.
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
wikipathwaysWP382MAPK Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD289Parthenolide1
iGMDRD782DC-45-A25
iGMDRD294Batimastat1
iGMDRD870BRD636102
iGMDRD353PD03259011
iGMDRD414MST-3123
iGMDRD188Piperlongumine2
iGMDRD577BIX012944
iGMDRD562Navitoclax2
iGMDRD560MK-22063
iGMDRD345Compound 10b [PMID: 11504634]2
iGMDRD483SCH-5290741
iGMDRD494Neopeltolide2
iGMDRD126Tipifarnib2
iGMDRD512nutlin 32
iGMDRD177Teniposide2
iGMDRD280CYTOCHALASIN B1
iGMDRD634SCHEMBL26080415
iGMDRD945ML2143
iGMDRD85Ursolic acid2
iGMDRD61Kinetin riboside1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TAOK2

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