TOPBP1


Summary: This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
DNA topoisomerase II binding protein 1MIM:607760Ensembl:ENSG00000163781HGNC:HGNC:17008PA1349340733q22.1

GO terms in TOPBP1


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003677DNA binding
MFIPIGO:0005515protein binding
MFTASGO:0008022protein C-terminus binding
MFIPIGO:0042802identical protein binding
CCIEAGO:0000794condensed nuclear chromosome
CCIEAGO:0000922spindle pole
CCIEAGO:0001673male germ cell nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIDAGO:0005694chromosome
CCIEAGO:0005737cytoplasm
CCIEAGO:0005815microtubule organizing center
CCIDAGO:0015629actin cytoskeleton
CCIDAGO:0016604nuclear body
CCIDAGO:0016605PML body
BPTASGO:0006259DNA metabolic process
BPNASGO:0006281DNA repair
BPIDAGO:0006974cellular response to DNA damage stimulus
BPIDAGO:0010212response to ionizing radiation
BPIBAGO:0033314mitotic DNA replication checkpoint

Gene expression in normal tissue: TOPBP1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TOPBP1


DatabasePathway IDPathway Des.
pidatr_pathwayATR signaling pathway
pidbard1pathwayBARD1 signaling events
pide2f_pathwayE2F transcription factor network
pidfanconi_pathwayFanconi anemia pathway
kegghsa03440Homologous recombination - Homo sapiens (human)
wikipathwaysWP3875ATR Signaling
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-3700989Transcriptional Regulation by TP53
reactomeR-HSA-5633007Regulation of TP53 Activity
reactomeR-HSA-5685938HDR through Single Strand Annealing (SSA)
reactomeR-HSA-5685942HDR through Homologous Recombination (HRR)
reactomeR-HSA-5693532DNA Double-Strand Break Repair
reactomeR-HSA-5693538Homology Directed Repair
reactomeR-HSA-5693567HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
reactomeR-HSA-5693579Homologous DNA Pairing and Strand Exchange
reactomeR-HSA-5693607Processing of DNA double-strand break ends
reactomeR-HSA-5693616Presynaptic phase of homologous DNA pairing and strand exchange
reactomeR-HSA-6804756Regulation of TP53 Activity through Phosphorylation
reactomeR-HSA-69473G2/M DNA damage checkpoint
reactomeR-HSA-69481G2/M Checkpoints
reactomeR-HSA-69620Cell Cycle Checkpoints
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-73894DNA Repair
reactomeR-HSA-74160Gene expression (Transcription)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD394BX-7952
iGMDRD57Chloropentafluorobenzene2
iGMDRD781Sirolimus3
iGMDRD248BRD43541
iGMDRD425ERASTIN2
iGMDRD60Quinoclamine2
iGMDRD353PD03259011
iGMDRD630ML2033
iGMDRD414MST-3122
iGMDRD399Selumetinib2
iGMDRD662JQ-13
iGMDRD329Merck606
iGMDRD398Sepantronium2
iGMDRD289Parthenolide2
iGMDRD221Tamoxifen6
iGMDRD192CIL564
iGMDRD271Brefeldin A3
iGMDRD138PX 122
iGMDRD137Indisulam2
iGMDRD5Tyrphostin AG 14785

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOPBP1

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