BAG4
Summary: The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BCL2 associated athanogene 4 | MIM:603884 | Ensembl:ENSG00000156735 | HGNC:HGNC:940 | PA25240 | 8p11.23 |
GO terms in BAG4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0000774 | adenyl-nucleotide exchange factor activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IEA | GO:0051087 | chaperone binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| BP | TAS | GO:0006457 | protein folding |
| BP | IEA | GO:0010763 | positive regulation of fibroblast migration |
| BP | IEA | GO:0030838 | positive regulation of actin filament polymerization |
| BP | IEA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0045785 | positive regulation of cell adhesion |
| BP | IEA | GO:0051291 | protein heterooligomerization |
| BP | IEA | GO:0051496 | positive regulation of stress fiber assembly |
| BP | IEA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IEA | GO:0072659 | protein localization to plasma membrane |
| BP | IEA | GO:0090367 | negative regulation of mRNA modification |
| BP | IEA | GO:0097178 | ruffle assembly |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| BP | IMP | GO:1903215 | negative regulation of protein targeting to mitochondrion |
| BP | IEA | GO:2001145 | negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity |
Gene expression in normal tissue: BAG4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BAG4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | tnfpathway | TNF receptor signaling pathway |
| netpath | Pathway_TNFalpha | TNFalpha |
| wikipathways | WP3941 | Oxidative Damage |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
| reactome | R-HSA-8853336 | Signaling by plasma membrane FGFR1 fusions |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | soddpathway | sodd/tnfr1 signaling pathway |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tnfr1pathway | tnfr1 signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD882 | CIL41 | 1 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD802 | 4-methylfasudil | 2 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD219 | Bax channel blocker | 2 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD883 | CIL55A | 2 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD483 | SCH-529074 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BAG4
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