PTGS2
Summary: Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| prostaglandin-endoperoxide synthase 2 | MIM:600262 | Ensembl:ENSG00000073756 | HGNC:HGNC:9605 | PA293 | 1q31.1 |
GO terms in PTGS2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | NAS | GO:0004601 | peroxidase activity |
| MF | TAS | GO:0004601 | peroxidase activity |
| MF | IDA | GO:0004666 | prostaglandin-endoperoxide synthase activity |
| MF | TAS | GO:0004666 | prostaglandin-endoperoxide synthase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | ISS | GO:0020037 | heme binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | TAS | GO:0050473 | arachidonate 15-lipoxygenase activity |
| BP | ISS | GO:0001516 | prostaglandin biosynthetic process |
| BP | NAS | GO:0001516 | prostaglandin biosynthetic process |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IEA | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0007566 | embryo implantation |
| BP | IEA | GO:0007568 | aging |
| BP | IEA | GO:0007612 | learning |
| BP | IEA | GO:0007613 | memory |
| BP | ISS | GO:0008217 | regulation of blood pressure |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0009750 | response to fructose |
| BP | IEA | GO:0010042 | response to manganese ion |
| BP | IEA | GO:0010226 | response to lithium ion |
| BP | ISS | GO:0010575 | positive regulation of vascular endothelial growth factor production |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0019233 | sensory perception of pain |
| BP | IDA | GO:0019371 | cyclooxygenase pathway |
| BP | TAS | GO:0019371 | cyclooxygenase pathway |
| BP | TAS | GO:0019372 | lipoxygenase pathway |
| BP | IEA | GO:0030282 | bone mineralization |
| BP | IEA | GO:0030728 | ovulation |
| BP | NAS | GO:0031394 | positive regulation of prostaglandin biosynthetic process |
| BP | ISS | GO:0031622 | positive regulation of fever generation |
| BP | IEA | GO:0031915 | positive regulation of synaptic plasticity |
| BP | IEA | GO:0032227 | negative regulation of synaptic transmission, dopaminergic |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IEA | GO:0033280 | response to vitamin D |
| BP | TAS | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway |
| BP | IEA | GO:0034605 | cellular response to heat |
| BP | IEA | GO:0034612 | response to tumor necrosis factor |
| BP | IEA | GO:0034644 | cellular response to UV |
| BP | IEA | GO:0035633 | maintenance of permeability of blood-brain barrier |
| BP | IEA | GO:0042307 | positive regulation of protein import into nucleus |
| BP | IEA | GO:0042633 | hair cycle |
| BP | TAS | GO:0042759 | long-chain fatty acid biosynthetic process |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | ISS | GO:0045429 | positive regulation of nitric oxide biosynthetic process |
| BP | IEA | GO:0045786 | negative regulation of cell cycle |
| BP | IEA | GO:0045907 | positive regulation of vasoconstriction |
| BP | IEA | GO:0045986 | negative regulation of smooth muscle contraction |
| BP | IEA | GO:0045987 | positive regulation of smooth muscle contraction |
| BP | IEA | GO:0046697 | decidualization |
| BP | IEA | GO:0048661 | positive regulation of smooth muscle cell proliferation |
| BP | NAS | GO:0050727 | regulation of inflammatory response |
| BP | IEA | GO:0050873 | brown fat cell differentiation |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| BP | IEA | GO:0051926 | negative regulation of calcium ion transport |
| BP | IEA | GO:0051968 | positive regulation of synaptic transmission, glutamatergic |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0070542 | response to fatty acid |
| BP | IEA | GO:0071260 | cellular response to mechanical stimulus |
| BP | IEA | GO:0071284 | cellular response to lead ion |
| BP | IEA | GO:0071318 | cellular response to ATP |
| BP | IEP | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:0071471 | cellular response to non-ionic osmotic stress |
| BP | IEA | GO:0071498 | cellular response to fluid shear stress |
| BP | ISS | GO:0071636 | positive regulation of transforming growth factor beta production |
| BP | ISS | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis |
| BP | ISS | GO:0090271 | positive regulation of fibroblast growth factor production |
| BP | ISS | GO:0090336 | positive regulation of brown fat cell differentiation |
| BP | ISS | GO:0090362 | positive regulation of platelet-derived growth factor production |
| BP | IEA | GO:0097756 | negative regulation of blood vessel diameter |
| BP | IEA | GO:0098869 | cellular oxidant detoxification |
| BP | IEA | GO:1902219 | negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress |
| BP | IEA | GO:1990776 | response to angiotensin |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IEA | GO:0005901 | caveola |
| CC | IEA | GO:0031090 | organelle membrane |
| CC | IEA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0043005 | neuron projection |
Gene expression in normal tissue: PTGS2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PTGS2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-196807 | Nicotinate metabolism |
| reactome | R-HSA-196849 | Metabolism of water-soluble vitamins and cofactors |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-197264 | Nicotinamide salvaging |
| reactome | R-HSA-2142753 | Arachidonic acid metabolism |
| reactome | R-HSA-2142770 | Synthesis of 15-eicosatetraenoic acid derivatives |
| reactome | R-HSA-2162123 | Synthesis of Prostaglandins (PG) and Thromboxanes (TX) |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-6783783 | Interleukin-10 signaling |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| reactome | R-HSA-9018677 | Biosynthesis of DHA-derived SPMs |
| reactome | R-HSA-9018678 | Biosynthesis of specialized proresolving mediators (SPMs) |
| reactome | R-HSA-9018679 | Biosynthesis of EPA-derived SPMs |
| reactome | R-HSA-9018683 | Biosynthesis of DPA-derived SPMs |
| reactome | R-HSA-9025094 | Biosynthesis of DPAn-3 SPMs |
| reactome | R-HSA-9027604 | Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives |
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| pid | s1p_s1p1_pathway | S1P1 pathway |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
| pharmgkb | PA152241951 | Celecoxib Pathway, Pharmacodynamics |
| pharmgkb | PA165986194 | Pathway_PA165986194 -need delete |
| pharmgkb | PA165986279 | Acetaminophen Pathway, Pharmacokinetics |
| pharmgkb | PA2025 | Etoposide Pathway, Pharmacokinetics/Pharmacodynamics |
| humancyc | PWY66-374 | C20 prostanoid biosynthesis |
| humancyc | PWY66-393 | aspirin-triggered lipoxin biosynthesis |
| humancyc | PWY66-394 | aspirin triggered resolvin E biosynthesis |
| humancyc | PWY66-395 | aspirin triggered resolvin D biosynthesis |
| kegg | hsa00590 | Arachidonic acid metabolism - Homo sapiens (human) |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04913 | Ovarian steroidogenesis - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04923 | Regulation of lipolysis in adipocytes - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05204 | Chemical carcinogenesis - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| smpdb | SMP00075 | Arachidonic Acid Metabolism |
| smpdb | SMP00077 | Piroxicam Action Pathway |
| smpdb | SMP00083 | Acetylsalicylic Acid Action Pathway |
| smpdb | SMP00084 | Etodolac Action Pathway |
| smpdb | SMP00085 | Ketoprofen Action Pathway |
| smpdb | SMP00086 | Ibuprofen Action Pathway |
| smpdb | SMP00087 | Rofecoxib Action Pathway |
| smpdb | SMP00093 | Diclofenac Action Pathway |
| smpdb | SMP00094 | Sulindac Action Pathway |
| smpdb | SMP00096 | Celecoxib Action Pathway |
| smpdb | SMP00098 | Ketorolac Action Pathway |
| smpdb | SMP00101 | Suprofen Action Pathway |
| smpdb | SMP00102 | Bromfenac Action Pathway |
| smpdb | SMP00104 | Indomethacin Action Pathway |
| smpdb | SMP00106 | Meloxicam Action Pathway |
| smpdb | SMP00109 | Mefenamic Acid Action Pathway |
| smpdb | SMP00113 | Oxaprozin Action Pathway |
| smpdb | SMP00114 | Nabumetone Action Pathway |
| smpdb | SMP00116 | Valdecoxib Action Pathway |
| smpdb | SMP00120 | Naproxen Action Pathway |
| smpdb | SMP00289 | Diflunisal Action Pathway |
| smpdb | SMP00353 | Leukotriene C4 Synthesis Deficiency |
| smpdb | SMP00442 | Etoposide Action Pathway |
| smpdb | SMP00590 | Ibuprofen Metabolism Pathway |
| smpdb | SMP00601 | Etoposide Metabolism Pathway |
| smpdb | SMP00644 | Celecoxib Metabolism Pathway |
| smpdb | SMP00692 | Antipyrine Action Pathway |
| smpdb | SMP00693 | Antrafenine Action Pathway |
| smpdb | SMP00694 | Carprofen Action Pathway |
| smpdb | SMP00695 | Etoricoxib Action Pathway |
| smpdb | SMP00696 | Fenoprofen Action Pathway |
| smpdb | SMP00697 | Flurbiprofen Action Pathway |
| smpdb | SMP00698 | Magnesium salicylate Action Pathway |
| smpdb | SMP00699 | Lumiracoxib Action Pathway |
| smpdb | SMP00700 | Lornoxicam Action Pathway |
| smpdb | SMP00701 | Phenylbutazone Action Pathway |
| smpdb | SMP00702 | Nepafenac Action Pathway |
| smpdb | SMP00703 | Trisalicylate-choline Action Pathway |
| smpdb | SMP00704 | Tolmetin Action Pathway |
| smpdb | SMP00705 | Tiaprofenic Acid Action Pathway |
| smpdb | SMP00706 | Tenoxicam Action Pathway |
| smpdb | SMP00707 | Salsalate Action Pathway |
| smpdb | SMP00708 | Salicylate-sodium Action Pathway |
| smpdb | SMP00709 | Salicylic Acid Action Pathway |
| smpdb | SMP00710 | Acetaminophen Action Pathway |
| wikipathways | WP15 | Selenium Micronutrient Network |
| wikipathways | WP167 | Eicosanoid Synthesis |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2435 | Quercetin and Nf-kB- AP-1 Induced Cell Apoptosis |
| wikipathways | WP2586 | Aryl Hydrocarbon Receptor |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP3287 | Overview of nanoparticle effects |
| wikipathways | WP3614 | Photodynamic therapy-induced HIF-1 survival signaling |
| wikipathways | WP3617 | Photodynamic therapy-induced NF-kB survival signaling |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4026 | Gastric ulcer formation |
| wikipathways | WP4063 | Interleukin-10 signaling |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP98 | Prostaglandin Synthesis and Regulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 9 |
| iGMDRD679 | Bistramide A | 5 |
| iGMDRD57 | Chloropentafluorobenzene | 6 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD10 | Aspirin | 1 |
| iGMDRD76 | Simvastatin | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD300 | Tozasertib | 8 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD780 | PP-30 | 1 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD251 | ML162 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PTGS2
CLASSFICATION
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