CTLA4


Summary: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
cytotoxic T-lymphocyte associated protein 4MIM:123890Ensembl:ENSG00000163599HGNC:HGNC:2505PA270062q33.2

GO terms in CTLA4


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0005515protein binding
CCIDAGO:0005794Golgi apparatus
CCTASGO:0005886plasma membrane
CCIMPGO:0005887integral component of plasma membrane
CCIDAGO:0009897external side of plasma membrane
CCIDAGO:0045334clathrin-coated endocytic vesicle
CCIDAGO:0048471perinuclear region of cytoplasm
CCIDAGO:0098636protein complex involved in cell adhesion
BPIEAGO:0002250adaptive immune response
BPTASGO:0006955immune response
BPIMPGO:0006974cellular response to DNA damage stimulus
BPIMPGO:0030889negative regulation of B cell proliferation
BPTASGO:0031295T cell costimulation
BPIEAGO:0042130negative regulation of T cell proliferation
BPIMPGO:0043065positive regulation of apoptotic process
BPTASGO:0045589regulation of regulatory T cell differentiation
BPIDAGO:0045590negative regulation of regulatory T cell differentiation
BPIEAGO:0050777negative regulation of immune response
BPIMPGO:0050853B cell receptor signaling pathway

Gene expression in normal tissue: CTLA4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CTLA4


DatabasePathway IDPathway Des.
biocartactla4pathwaythe co-stimulatory signal during t-cell activation
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-212436Generic Transcription Pathway
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389513CTLA4 inhibitory signaling
reactomeR-HSA-73857RNA Polymerase II Transcription
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8877330RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
reactomeR-HSA-8878171Transcriptional regulation by RUNX1
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2583T-Cell Receptor and Co-stimulatory Signaling
wikipathwaysWP2877Vitamin D Receptor Pathway
wikipathwaysWP3863T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection
wikipathwaysWP4079RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa05320Autoimmune thyroid disease - Homo sapiens (human)
kegghsa05323Rheumatoid arthritis - Homo sapiens (human)
pidnfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
netpathPathway_TCRTCR

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD642Skepinone-L1
iGMDRD137Indisulam5
iGMDRD318PAC-13
iGMDRD372TGX 2211
iGMDRD87Epigallocatechin-3-monogallate2
iGMDRD577BIX012942
iGMDRD506Fedratinib2
iGMDRD562Navitoclax3
iGMDRD398Sepantronium3
iGMDRD505Pevonedistat8
iGMDRD60Quinoclamine2
iGMDRD409Saracatinib1
iGMDRD387CHIR-990213
iGMDRD889Compound 7d-cis3
iGMDRD628BRD-K551167081
iGMDRD370TPCA-11
iGMDRD150RITA5
iGMDRD456Crizotinib1
iGMDRD239Dasatinib1
iGMDRD427ABT7376
iGMDRD256NVP-2311
iGMDRD484Pluripotin1
iGMDRD358Semagacestat2
iGMDRD676Birinapant1
iGMDRD634SCHEMBL26080413

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTLA4

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