SEARCH

HOME / SEARCH / FOXO4

FOXO4

Summary: This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
forkhead box O4	MIM:300033	Ensembl:ENSG00000184481	HGNC:HGNC:7139	PA162388882	Xq13.1

Gene Categories:

TUMOR SUPPRESSOR TRANSCRIPTION FACTOR BINDING

GO terms in FOXO4

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0000122	negative regulation of transcription by RNA polymerase II
BP	IDA	GO:0006355	regulation of transcription, DNA-templated
BP	TAS	GO:0006366	transcription by RNA polymerase II
BP	IDA	GO:0007050	cell cycle arrest
BP	IEA	GO:0007095	mitotic G2 DNA damage checkpoint
BP	IEA	GO:0007517	muscle organ development
BP	IEA	GO:0007568	aging
BP	IDA	GO:0008285	negative regulation of cell proliferation
BP	IBA	GO:0008286	insulin receptor signaling pathway
BP	IDA	GO:0008286	insulin receptor signaling pathway
BP	IEA	GO:0014911	positive regulation of smooth muscle cell migration
BP	IDA	GO:0016525	negative regulation of angiogenesis
BP	TAS	GO:0016579	protein deubiquitination
BP	IEA	GO:0031667	response to nutrient levels
BP	IBA	GO:0042593	glucose homeostasis
BP	IBA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IDA	GO:0045944	positive regulation of transcription by RNA polymerase II
BP	IMP	GO:0048863	stem cell differentiation
BP	IDA	GO:0051151	negative regulation of smooth muscle cell differentiation
BP	IDA	GO:0070317	negative regulation of G0 to G1 transition
BP	IDA	GO:0071158	positive regulation of cell cycle arrest
BP	IEA	GO:1990785	response to water-immersion restraint stress
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005737	cytoplasm
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0016607	nuclear speck
MF	IBA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	NAS	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IC	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MF	IDA	GO:0003677	DNA binding
MF	IBA	GO:0003700	DNA-binding transcription factor activity
MF	IDA	GO:0003700	DNA-binding transcription factor activity
MF	IPI	GO:0005515	protein binding
MF	IDA	GO:0008013	beta-catenin binding
MF	IBA	GO:0008134	transcription factor binding
MF	IPI	GO:0008134	transcription factor binding
MF	IPI	GO:0019899	enzyme binding
MF	IPI	GO:0042802	identical protein binding
MF	IBA	GO:0043565	sequence-specific DNA binding
MF	IDA	GO:0043565	sequence-specific DNA binding
MF	IMP	GO:0043565	sequence-specific DNA binding
MF	IEA	GO:1990841	promoter-specific chromatin binding

Gene expression in normal tissue: FOXO4

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FOXO4

Database	Pathway ID	Pathway Des.
biocarta	aktpathway	akt signaling pathway
biocarta	raspathway	ras signaling pathway
reactome	R-HSA-1257604	PIP3 activates AKT signaling
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1643685	Disease
reactome	R-HSA-198693	AKT phosphorylates targets in the nucleus
reactome	R-HSA-2219528	PI3K/AKT Signaling in Cancer
reactome	R-HSA-392499	Metabolism of proteins
reactome	R-HSA-5663202	Diseases of signal transduction
reactome	R-HSA-5674400	Constitutive Signaling by AKT1 E17K in Cancer
reactome	R-HSA-5688426	Deubiquitination
reactome	R-HSA-5689880	Ub-specific processing proteases
reactome	R-HSA-597592	Post-translational protein modification
reactome	R-HSA-9006925	Intracellular signaling by second messengers
wikipathways	WP2261	Signaling Pathways in Glioblastoma
wikipathways	WP2324	AGE-RAGE pathway
wikipathways	WP3844	PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
wikipathways	WP3888	VEGFA-VEGFR2 Signaling Pathway
wikipathways	WP4223	Ras Signaling
wikipathways	WP437	EGF-EGFR Signaling Pathway
kegg	hsa04014	Ras signaling pathway - Homo sapiens (human)
kegg	hsa04068	FoxO signaling pathway - Homo sapiens (human)
pid	foxopathway	FoxO family signaling
pid	hdac_classiii_pathway	Signaling events mediated by HDAC Class III
pid	pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
pid	smad2_3nuclearpathway	Regulation of nuclear SMAD2/3 signaling
netpath	Pathway_EGFR1	EGFR1
netpath	Pathway_IL6	IL6
netpath	Pathway_TGF_beta_Receptor	TGF_beta_Receptor

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD781	Sirolimus	1
iGMDRD494	Neopeltolide	2
iGMDRD424	Tamatinib	2
iGMDRD512	nutlin 3	2
iGMDRD466	Chaetocin	2
iGMDRD394	BX-795	2
iGMDRD280	CYTOCHALASIN B	3
iGMDRD211	(1S,3R)-RSL3	2
iGMDRD152	179324-69-7	3
iGMDRD219	Bax channel blocker	1
iGMDRD870	BRD63610	4
iGMDRD318	PAC-1	3
iGMDRD121	GMX1778	2
iGMDRD322	FK 866	2
iGMDRD246	NPC26	2
iGMDRD886	Compound 1541A	3
iGMDRD300	Tozasertib	2
iGMDRD286	Nsc 632839	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FOXO4

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.