MAP3K10
Summary: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase kinase kinase 10 | MIM:600137 | Ensembl:ENSG00000130758 | HGNC:HGNC:6849 | PA30593 | 19q13.2 |
GO terms in MAP3K10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005737 | cytoplasm |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IMP | GO:0007224 | smoothened signaling pathway |
| BP | TAS | GO:0007254 | JNK cascade |
| BP | IEA | GO:0007256 | activation of JNKK activity |
| BP | IBA | GO:0007257 | activation of JUN kinase activity |
| BP | ISS | GO:0007257 | activation of JUN kinase activity |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IBA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043433 | negative regulation of DNA-binding transcription factor activity |
| BP | IMP | GO:0043507 | positive regulation of JUN kinase activity |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0046330 | positive regulation of JNK cascade |
| BP | ISS | GO:0046777 | protein autophosphorylation |
| MF | ISS | GO:0003714 | transcription corepressor activity |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004706 | JUN kinase kinase kinase activity |
| MF | ISS | GO:0004706 | JUN kinase kinase kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0043425 | bHLH transcription factor binding |
Gene expression in normal tissue: MAP3K10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAP3K10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | p38_mkk3_6pathway | p38 MAPK signaling pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD870 | BRD63610 | 6 |
| iGMDRD105 | Triptolide | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAP3K10
CLASSFICATION
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