MAPK7
Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| mitogen-activated protein kinase 7 | MIM:602521 | Ensembl:ENSG00000166484 | HGNC:HGNC:6880 | PA30625 | 17p11.2 |
GO terms in MAPK7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004707 | MAP kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0051019 | mitogen-activated protein kinase binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016605 | PML body |
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0007049 | cell cycle |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IBA | GO:0010468 | regulation of gene expression |
| BP | IEA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | NAS | GO:0019933 | cAMP-mediated signaling |
| BP | IGI | GO:0034115 | negative regulation of heterotypic cell-cell adhesion |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IMP | GO:0036003 | positive regulation of transcription from RNA polymerase II promoter in response to stress |
| BP | IEA | GO:0043407 | negative regulation of MAP kinase activity |
| BP | IEA | GO:0045765 | regulation of angiogenesis |
| BP | IGI | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0050728 | negative regulation of inflammatory response |
| BP | IGI | GO:0051247 | positive regulation of protein metabolic process |
| BP | NAS | GO:0051344 | negative regulation of cyclic-nucleotide phosphodiesterase activity |
| BP | IGI | GO:0060761 | negative regulation of response to cytokine stimulus |
| BP | IMP | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IEA | GO:0070377 | negative regulation of ERK5 cascade |
| BP | IEA | GO:0070885 | negative regulation of calcineurin-NFAT signaling cascade |
| BP | IBA | GO:0071310 | cellular response to organic substance |
| BP | IGI | GO:0071363 | cellular response to growth factor stimulus |
| BP | IMP | GO:0071499 | cellular response to laminar fluid shear stress |
| BP | TAS | GO:0071499 | cellular response to laminar fluid shear stress |
| BP | IDA | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| BP | IMP | GO:1902176 | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| BP | IMP | GO:2000352 | negative regulation of endothelial cell apoptotic process |
| BP | IGI | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
Gene expression in normal tissue: MAPK7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MAPK7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166058 | MyD88:Mal cascade initiated on plasma membrane |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168142 | Toll Like Receptor 10 (TLR10) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168176 | Toll Like Receptor 5 (TLR5) Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168179 | Toll Like Receptor TLR1:TLR2 Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168188 | Toll Like Receptor TLR6:TLR2 Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-181438 | Toll Like Receptor 2 (TLR2) Cascade |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-187037 | Signaling by NTRK1 (TRKA) |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198725 | Nuclear Events (kinase and transcription factor activation) |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-198753 | ERK/MAPK targets |
| reactome | R-HSA-198765 | Signalling to ERK5 |
| reactome | R-HSA-198765 | Signalling to ERK5 |
| reactome | R-HSA-202670 | ERKs are inactivated |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-448424 | Interleukin-17 signaling |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450282 | MAPK targets/ Nuclear events mediated by MAP kinases |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-450294 | MAP kinase activation |
| reactome | R-HSA-881907 | Gastrin-CREB signalling pathway via PKC and MAPK |
| reactome | R-HSA-8853659 | RET signaling |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| reactome | R-HSA-975871 | MyD88 cascade initiated on plasma membrane |
| biocarta | erk5pathway | role of erk5 in neuronal survival pathway |
| biocarta | mapkpathway | mapkinase signaling pathway |
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Fibroblast__growth__factor-1 | Fibroblast growth factor-1 |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TCR | TCR |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP26 | Signal Transduction of S1P Receptor |
| wikipathways | WP2795 | Cardiac Hypertrophic Response |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP481 | Insulin Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 5 |
| iGMDRD945 | ML214 | 11 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD701 | NVP-AUY922 | 4 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD414 | MST-312 | 1 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD300 | Tozasertib | 9 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD271 | Brefeldin A | 5 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD802 | 4-methylfasudil | 1 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD221 | Tamoxifen | 2 |
| iGMDRD481 | Dactolisib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MAPK7
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.